Asymmetric synthesis of chiral 2-fluorinated 1,3-propanediols and its application to the preparation of monofluorinated chiral synthon

Hajime Yokoyama, Ryo Hyodo, Akiko Nakada, Seiji Yamaguchi, Yoshiro Hirai*, Tadashi Kometani, Michimasa Goto, Norio Shibata, Yoshio Takeuchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Asymmetric synthesis of optically active 2-fluorinated 1,3-propanediols was achieved by enzymatical resolution and applied to obtain a chiral monofluorinated synthon for lignan derivatives.

Original languageEnglish
Pages (from-to)7741-7744
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number42
DOIs
StatePublished - 1998/10/15

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

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