Association between preoperative biologic use and surgical morbidity in patients with Crohn’s disease

Motoi Uchino*, Hiroki Ikeuchi, Yuki Horio, Ryuichi Kuwahara, Tomohiro Minagawa, Kurando Kusunoki, Yoshiko Goto, Naohito Beppu, Kaoru Ichiki, Takashi Ueda, Kazuhiko Nakajima, Masataka Ikeda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose: We evaluated the influence of preoperative treatments with biologics on surgical morbidity in patients with Crohn’s disease (CD). Methods: We reviewed the surveillance data of patients with CD who underwent surgery between April 2018 and April 2021. The possible risk factors for morbidity were analyzed. Results: A total of 305 surgically treated patients were included. Anti-TNF alpha agents and ustekinumab were used in 92 and 27 patients, respectively, within 12 weeks before surgery. There were no cases of mortality. In total, 70/305 (23.0%) patients developed a complication, and 42/305 (13.8%) patients developed a surgical site infection (SSI) (17 incisional SSIs and 35 organ/space SSIs). Current smoking status (OR 3.44), emergent/urgent surgery (OR 6.85), and abdominoperineal resection (APR) (OR 14.93) were identified as risk factors for total complications. Penetrating disease (OR 14.55) was identified as a risk factor for incisional SSIs. Current smoking status (OR 7.09), an American Society of Anesthesiologists (ASA) score greater than 3 (OR 5.85), a postoperative blood sugar level over 155 mg/dL (OR 4.37), and APR (OR 207.95) were identified as risk factors for organ/space SSIs. Conclusions: No correlation between preoperative treatment with biologics and surgical mortality or morbidity was found. However, we should perform further analyses on a larger number of patients because the analyses may be limited by selection bias for treatment and several confounding factors.

Original languageEnglish
Pages (from-to)999-1010
Number of pages12
JournalInternational Journal of Colorectal Disease
Volume37
Issue number5
DOIs
StatePublished - 2022/05

Keywords

  • Biologics
  • Crohn’s disease
  • Morbidity
  • Surgery
  • Surgical site infection

ASJC Scopus subject areas

  • Gastroenterology

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