Abstract
We investigated the inhibitory effect of Juzen-taiho--o in an experimental liver metastasis model, by means of inoculation of a highly liver-metastatic variant (L5) of murine colon 26 carcinoma cells into the portal vein. Oral administration of Juzen-taiho-to before tumor inoculation resulted in the dosedependent inhibition of liver tumor colonies. Oral administration of Juzen-taiho-to for 7 days before tumor inoculation led to a significant reduction in the number of metastatic colonies and liver weight even in NK-depleted mice as well as normal mice, but not in macrophage- deficient mice. This finding shows that the inhibition of metastasis by Juzen-taiho-to is associated with macrophage function.
| Original language | English |
|---|---|
| Pages (from-to) | 187-189 |
| Number of pages | 3 |
| Journal | Biotherapy |
| Volume | 12 |
| Issue number | 1 |
| State | Published - 1998 |
Keywords
- Colon 26-L5
- Juzen-taiho-to
- Liver metastasis
ASJC Scopus subject areas
- Oncology
- Cancer Research
