Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang

Soo Jin Lee; Ikuo Saiki; Yoshihiro Hayakawa; Shinyu Nunome; Haruki Yamada; Sung Hoon Kim

doi:10.1016/S1567-5769(02)00091-7

Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang

Soo Jin Lee, Ikuo Saiki, Yoshihiro Hayakawa, Shinyu Nunome, Haruki Yamada, Sung Hoon Kim^*

^*Corresponding author for this work

Section of Host Defences, Division of Bioscience, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We investigated the antimetastatic effect of Bojung-bangam-tang, a new herbal prescription, on liver metastasis by the inoculation of colon 26-L5 carcinoma cells into the portal vein. Oral administration of Bojung-bangam-tang for 15 days from day 7 before tumor inoculation significantly inhibited liver metastasis in a dose-dependent manner. Bojung-bangam-tang enhanced the mitogenic activity of BALB/c whole splenocytes induced by various mitogenic stimuli. Oral administration of Bojung-bangam-tang, by itself, could not induce the production of interleukin (IL)-12 or IFN-γ by macrophages, but enhanced the potential of macrophages to produce cytokines in response to lipopolysaccharide (LPS). Experiments using macrophage- or natural killer (NK) cell-deficient mice revealed that the antimetastatic effect of Bojung-bangam-tang is mediated by macrophages rather than NK cells. Bojung-bangam-tang caused a marked increase of production of Th1 cytokine (IFN-γ) and decrease of production of Th2 cytokine (IL-4) by splenocytes stimulated with concanavalin A (Con A). These results indicated that oral administration of Bojung-bangam-tang inhibited the liver metastasis of colon 26-L5 cells through a mechanism leading to a Th1 dominant immune state and activation of macrophages. Thus, Bojung-bangam-tang may be useful for the prevention of cancer metastasis.

Original language	English
Pages (from-to)	147-157
Number of pages	11
Journal	International Immunopharmacology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/S1567-5769(02)00091-7
State	Published - 2003/02

Keywords

Cytokines
Helper T cell
Macrophages
Traditional herbal prescription
Tumor metastasis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1567-5769(02)00091-7

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title = "Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang",

abstract = "We investigated the antimetastatic effect of Bojung-bangam-tang, a new herbal prescription, on liver metastasis by the inoculation of colon 26-L5 carcinoma cells into the portal vein. Oral administration of Bojung-bangam-tang for 15 days from day 7 before tumor inoculation significantly inhibited liver metastasis in a dose-dependent manner. Bojung-bangam-tang enhanced the mitogenic activity of BALB/c whole splenocytes induced by various mitogenic stimuli. Oral administration of Bojung-bangam-tang, by itself, could not induce the production of interleukin (IL)-12 or IFN-γ by macrophages, but enhanced the potential of macrophages to produce cytokines in response to lipopolysaccharide (LPS). Experiments using macrophage- or natural killer (NK) cell-deficient mice revealed that the antimetastatic effect of Bojung-bangam-tang is mediated by macrophages rather than NK cells. Bojung-bangam-tang caused a marked increase of production of Th1 cytokine (IFN-γ) and decrease of production of Th2 cytokine (IL-4) by splenocytes stimulated with concanavalin A (Con A). These results indicated that oral administration of Bojung-bangam-tang inhibited the liver metastasis of colon 26-L5 cells through a mechanism leading to a Th1 dominant immune state and activation of macrophages. Thus, Bojung-bangam-tang may be useful for the prevention of cancer metastasis.",

keywords = "Cytokines, Helper T cell, Macrophages, Traditional herbal prescription, Tumor metastasis",

author = "Lee, {Soo Jin} and Ikuo Saiki and Yoshihiro Hayakawa and Shinyu Nunome and Haruki Yamada and Kim, {Sung Hoon}",

note = "Funding Information: This study was supported in part by a Grant-in-Aid for Cancer Research (no. 12217050) from the Japanese Ministry of Education, Culture, Sports, Science and Technology, Japan, the Brain Korea 21 Project and a Grant of Korea Research Science and Engineering Foundation (no. R01-2000-00101), Korea. ",

year = "2003",

month = feb,

doi = "10.1016/S1567-5769(02)00091-7",

language = "英語",

volume = "3",

pages = "147--157",

journal = "International Immunopharmacology",

issn = "1567-5769",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang

AU - Lee, Soo Jin

AU - Saiki, Ikuo

AU - Hayakawa, Yoshihiro

AU - Nunome, Shinyu

AU - Yamada, Haruki

AU - Kim, Sung Hoon

N1 - Funding Information: This study was supported in part by a Grant-in-Aid for Cancer Research (no. 12217050) from the Japanese Ministry of Education, Culture, Sports, Science and Technology, Japan, the Brain Korea 21 Project and a Grant of Korea Research Science and Engineering Foundation (no. R01-2000-00101), Korea.

PY - 2003/2

Y1 - 2003/2

N2 - We investigated the antimetastatic effect of Bojung-bangam-tang, a new herbal prescription, on liver metastasis by the inoculation of colon 26-L5 carcinoma cells into the portal vein. Oral administration of Bojung-bangam-tang for 15 days from day 7 before tumor inoculation significantly inhibited liver metastasis in a dose-dependent manner. Bojung-bangam-tang enhanced the mitogenic activity of BALB/c whole splenocytes induced by various mitogenic stimuli. Oral administration of Bojung-bangam-tang, by itself, could not induce the production of interleukin (IL)-12 or IFN-γ by macrophages, but enhanced the potential of macrophages to produce cytokines in response to lipopolysaccharide (LPS). Experiments using macrophage- or natural killer (NK) cell-deficient mice revealed that the antimetastatic effect of Bojung-bangam-tang is mediated by macrophages rather than NK cells. Bojung-bangam-tang caused a marked increase of production of Th1 cytokine (IFN-γ) and decrease of production of Th2 cytokine (IL-4) by splenocytes stimulated with concanavalin A (Con A). These results indicated that oral administration of Bojung-bangam-tang inhibited the liver metastasis of colon 26-L5 cells through a mechanism leading to a Th1 dominant immune state and activation of macrophages. Thus, Bojung-bangam-tang may be useful for the prevention of cancer metastasis.

AB - We investigated the antimetastatic effect of Bojung-bangam-tang, a new herbal prescription, on liver metastasis by the inoculation of colon 26-L5 carcinoma cells into the portal vein. Oral administration of Bojung-bangam-tang for 15 days from day 7 before tumor inoculation significantly inhibited liver metastasis in a dose-dependent manner. Bojung-bangam-tang enhanced the mitogenic activity of BALB/c whole splenocytes induced by various mitogenic stimuli. Oral administration of Bojung-bangam-tang, by itself, could not induce the production of interleukin (IL)-12 or IFN-γ by macrophages, but enhanced the potential of macrophages to produce cytokines in response to lipopolysaccharide (LPS). Experiments using macrophage- or natural killer (NK) cell-deficient mice revealed that the antimetastatic effect of Bojung-bangam-tang is mediated by macrophages rather than NK cells. Bojung-bangam-tang caused a marked increase of production of Th1 cytokine (IFN-γ) and decrease of production of Th2 cytokine (IL-4) by splenocytes stimulated with concanavalin A (Con A). These results indicated that oral administration of Bojung-bangam-tang inhibited the liver metastasis of colon 26-L5 cells through a mechanism leading to a Th1 dominant immune state and activation of macrophages. Thus, Bojung-bangam-tang may be useful for the prevention of cancer metastasis.

KW - Cytokines

KW - Helper T cell

KW - Macrophages

KW - Traditional herbal prescription

KW - Tumor metastasis

UR - http://www.scopus.com/inward/record.url?scp=0037315913&partnerID=8YFLogxK

U2 - 10.1016/S1567-5769(02)00091-7

DO - 10.1016/S1567-5769(02)00091-7

M3 - 学術論文

C2 - 12586596

AN - SCOPUS:0037315913

SN - 1567-5769

VL - 3

SP - 147

EP - 157

JO - International Immunopharmacology

JF - International Immunopharmacology

IS - 2

ER -

Antimetastatic and immunomodulating properties of a new herbal prescription, Bojung-bangam-tang

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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