Anti-myelin oligodendrocyte glycoprotein antibody-associated disease presenting tumefactive demyelinating lesions and bilateral optic neuritis with chiasmatic lesion

Takamasa Nukui; Noriyuki Matsuda; Hirofumi Konishi; Tomohiro Hayashi; Mamoru Yamamoto; Ryoko Shibuya; Hiroaki Hirosawa; Ryo Tanaka; Nobuhiro Dougu; Toshiyuki Takahashi; Yuji Nakatsuji

doi:10.1111/ncn3.12547

Anti-myelin oligodendrocyte glycoprotein antibody-associated disease presenting tumefactive demyelinating lesions and bilateral optic neuritis with chiasmatic lesion

Takamasa Nukui^*, Noriyuki Matsuda, Hirofumi Konishi, Tomohiro Hayashi, Mamoru Yamamoto, Ryoko Shibuya, Hiroaki Hirosawa, Ryo Tanaka, Nobuhiro Dougu, Toshiyuki Takahashi, Yuji Nakatsuji

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

A 15-year-old girl presented with a headache accompanied by bilateral visual impairment. Brain magnetic resonance imaging showed tumefactive lesions in the white matter of the right occipital lobe on fluid-attenuated inversion recovery images accompanied by open-ring gadolinium enhancement and high-intensity lesions in the bilateral optic nerve, including chiasma. Since anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected by blood examination, the patient was diagnosed with anti-MOG antibody-associated disease (MOGAD) exhibiting overlapping characteristics with tumefactive multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSDs). Steroid pulse therapy and plasma exchange therapy completely improved her symptoms, and oral prednisolone therapy prevented relapse of the disease for at least 2 years. Since MOGAD exhibits overlapping characteristics with MS and NMOSD, it is important to screen anti-MOG antibodies in patients with atypical MS and seronegative NMOSD.

Original language	English
Pages (from-to)	484-486
Number of pages	3
Journal	Neurology and Clinical Neuroscience
Volume	9
Issue number	6
DOIs	https://doi.org/10.1111/ncn3.12547
State	Published - 2021/11

Keywords

anti-myelin oligodendrocyte glycoprotein antibody
bilateral optic neuritis
tumefactive lesion

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/ncn3.12547

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Nukui, T., Matsuda, N., Konishi, H., Hayashi, T., Yamamoto, M., Shibuya, R., Hirosawa, H., Tanaka, R., Dougu, N., Takahashi, T., & Nakatsuji, Y. (2021). Anti-myelin oligodendrocyte glycoprotein antibody-associated disease presenting tumefactive demyelinating lesions and bilateral optic neuritis with chiasmatic lesion. Neurology and Clinical Neuroscience, 9(6), 484-486. https://doi.org/10.1111/ncn3.12547

@article{37268eeef83848239e79d962c2648434,

title = "Anti-myelin oligodendrocyte glycoprotein antibody-associated disease presenting tumefactive demyelinating lesions and bilateral optic neuritis with chiasmatic lesion",

abstract = "A 15-year-old girl presented with a headache accompanied by bilateral visual impairment. Brain magnetic resonance imaging showed tumefactive lesions in the white matter of the right occipital lobe on fluid-attenuated inversion recovery images accompanied by open-ring gadolinium enhancement and high-intensity lesions in the bilateral optic nerve, including chiasma. Since anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected by blood examination, the patient was diagnosed with anti-MOG antibody-associated disease (MOGAD) exhibiting overlapping characteristics with tumefactive multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSDs). Steroid pulse therapy and plasma exchange therapy completely improved her symptoms, and oral prednisolone therapy prevented relapse of the disease for at least 2 years. Since MOGAD exhibits overlapping characteristics with MS and NMOSD, it is important to screen anti-MOG antibodies in patients with atypical MS and seronegative NMOSD.",

keywords = "anti-myelin oligodendrocyte glycoprotein antibody, bilateral optic neuritis, tumefactive lesion",

author = "Takamasa Nukui and Noriyuki Matsuda and Hirofumi Konishi and Tomohiro Hayashi and Mamoru Yamamoto and Ryoko Shibuya and Hiroaki Hirosawa and Ryo Tanaka and Nobuhiro Dougu and Toshiyuki Takahashi and Yuji Nakatsuji",

note = "Publisher Copyright: {\textcopyright} 2021 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd",

year = "2021",

month = nov,

doi = "10.1111/ncn3.12547",

language = "英語",

volume = "9",

pages = "484--486",

journal = "Neurology and Clinical Neuroscience",

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number = "6",

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Nukui, T, Matsuda, N, Konishi, H, Hayashi, T , Yamamoto, M , Shibuya, R , Hirosawa, H , Tanaka, R, Dougu, N, Takahashi, T & Nakatsuji, Y 2021, 'Anti-myelin oligodendrocyte glycoprotein antibody-associated disease presenting tumefactive demyelinating lesions and bilateral optic neuritis with chiasmatic lesion', Neurology and Clinical Neuroscience, vol. 9, no. 6, pp. 484-486. https://doi.org/10.1111/ncn3.12547

Anti-myelin oligodendrocyte glycoprotein antibody-associated disease presenting tumefactive demyelinating lesions and bilateral optic neuritis with chiasmatic lesion. / Nukui, Takamasa; Matsuda, Noriyuki; Konishi, Hirofumi et al.
In: Neurology and Clinical Neuroscience, Vol. 9, No. 6, 11.2021, p. 484-486.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Anti-myelin oligodendrocyte glycoprotein antibody-associated disease presenting tumefactive demyelinating lesions and bilateral optic neuritis with chiasmatic lesion

AU - Nukui, Takamasa

AU - Matsuda, Noriyuki

AU - Konishi, Hirofumi

AU - Hayashi, Tomohiro

AU - Yamamoto, Mamoru

AU - Shibuya, Ryoko

AU - Hirosawa, Hiroaki

AU - Tanaka, Ryo

AU - Dougu, Nobuhiro

AU - Takahashi, Toshiyuki

AU - Nakatsuji, Yuji

PY - 2021/11

Y1 - 2021/11

N2 - A 15-year-old girl presented with a headache accompanied by bilateral visual impairment. Brain magnetic resonance imaging showed tumefactive lesions in the white matter of the right occipital lobe on fluid-attenuated inversion recovery images accompanied by open-ring gadolinium enhancement and high-intensity lesions in the bilateral optic nerve, including chiasma. Since anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected by blood examination, the patient was diagnosed with anti-MOG antibody-associated disease (MOGAD) exhibiting overlapping characteristics with tumefactive multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSDs). Steroid pulse therapy and plasma exchange therapy completely improved her symptoms, and oral prednisolone therapy prevented relapse of the disease for at least 2 years. Since MOGAD exhibits overlapping characteristics with MS and NMOSD, it is important to screen anti-MOG antibodies in patients with atypical MS and seronegative NMOSD.

AB - A 15-year-old girl presented with a headache accompanied by bilateral visual impairment. Brain magnetic resonance imaging showed tumefactive lesions in the white matter of the right occipital lobe on fluid-attenuated inversion recovery images accompanied by open-ring gadolinium enhancement and high-intensity lesions in the bilateral optic nerve, including chiasma. Since anti-myelin oligodendrocyte glycoprotein (MOG) antibody was detected by blood examination, the patient was diagnosed with anti-MOG antibody-associated disease (MOGAD) exhibiting overlapping characteristics with tumefactive multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSDs). Steroid pulse therapy and plasma exchange therapy completely improved her symptoms, and oral prednisolone therapy prevented relapse of the disease for at least 2 years. Since MOGAD exhibits overlapping characteristics with MS and NMOSD, it is important to screen anti-MOG antibodies in patients with atypical MS and seronegative NMOSD.

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EP - 486

JO - Neurology and Clinical Neuroscience

JF - Neurology and Clinical Neuroscience

IS - 6

ER -

Anti-myelin oligodendrocyte glycoprotein antibody-associated disease presenting tumefactive demyelinating lesions and bilateral optic neuritis with chiasmatic lesion

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Keywords

ASJC Scopus subject areas

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