Abstract
Objectives: We aimed to identify the clinical significance of anti-ganglionic nicotinic acetylcholine receptor α3 subunit (gAChRα3) antibodies (Abs) in patients with systemic lupus erythematosus (SLE). Methods: This retrospective study comprised adult patients with SLE who visited our hospital from 2006 through 2019. Anti-gAChRα3 Abs were measured in the sera of patients with SLE using a luciferase immunoprecipitation system assay. The clinical features of the patients with or without anti-gAChRα3 Abs were compared. We evaluated whether the Abs predict a specific manifestation and affect its development or relapse rate. Results: Among 144 patients, anti-gAChRα3 Abs were detected in 29 patients. Lupus enteritis (LE) was more frequently seen in anti-gAChRα3 Ab-positive patients than negative patients. The levels of anti-gAChRα3 Abs were significantly higher in patients with LE than those with other lupus manifestations. Logistic regression analysis revealed the anti-gAChRα3 Abs were independent predictors for LE (odds ratio 6.2, 95% confidence interval 1.9–20.3, p = .002). Kaplan–Meier analysis showed the rate of LE development or relapse from the time of sera collection was higher in anti-gAChRα3 Ab-positive patients than in negative patients (p < .001). Conclusion: Anti-gAChRα3 Abs could be a predictive biomarker for the development or relapse of LE.
Original language | English |
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Pages (from-to) | 154-159 |
Number of pages | 6 |
Journal | Modern Rheumatology |
Volume | 33 |
Issue number | 1 |
DOIs | |
State | Published - 2023/01/01 |
Keywords
- Anti-gAChRα3 antibody
- biomarker
- lupus enteritis
- systemic lupus erythematosus
ASJC Scopus subject areas
- General Medicine