Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex

Leena Suntornsuk; Keiichi Koizumi; Yurika Saitoh; Eliane Shizuka Nakamura; Naparat Kammasud; Opa Vajaragupta; Ikuo Saiki

doi:10.11339/jtm.21.94

Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex

Leena Suntornsuk, Keiichi Koizumi, Yurika Saitoh, Eliane Shizuka Nakamura, Naparat Kammasud, Opa Vajaragupta, Ikuo Saiki^*

^*Corresponding author for this work

Presymptomatic Disease, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative (curcumin ED) and curcumin ethylenediamine manganese complex (curcumin EDMn) through the inhibition of the formation of tube-like structures by human umbilical vascular endothelial cells (HUVEC). Curcumin, curcumin ED, curcumin EDMn did not show cytotoxicity to HUVEC at concentrations equal and lower than 10 μM. At the concentration of 10 μM, curcumin, curcumin ED and curcumin EDMn inhibited the tube formation by approximately 94%, 40% and 65%, respectively. These results suggest that curcumin ED and curcumin EDMn might be useful as anti-angiogenic drugs in addition to their anti-lipid peroxidase and superoxide dismutase activities as described in our previous studies.

Original language	English
Pages (from-to)	94-99
Number of pages	6
Journal	Journal of Traditional Medicines
Volume	21
Issue number	2
DOIs	https://doi.org/10.11339/jtm.21.94
State	Published - 2004

Keywords

angiogenesis
cancer
curcumin
human umbilical vascular endothelial cell
tube formation

ASJC Scopus subject areas

Drug Discovery
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11339/jtm.21.94

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title = "Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex",

abstract = "We investigated the anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative (curcumin ED) and curcumin ethylenediamine manganese complex (curcumin EDMn) through the inhibition of the formation of tube-like structures by human umbilical vascular endothelial cells (HUVEC). Curcumin, curcumin ED, curcumin EDMn did not show cytotoxicity to HUVEC at concentrations equal and lower than 10 μM. At the concentration of 10 μM, curcumin, curcumin ED and curcumin EDMn inhibited the tube formation by approximately 94%, 40% and 65%, respectively. These results suggest that curcumin ED and curcumin EDMn might be useful as anti-angiogenic drugs in addition to their anti-lipid peroxidase and superoxide dismutase activities as described in our previous studies.",

keywords = "angiogenesis, cancer, curcumin, human umbilical vascular endothelial cell, tube formation",

author = "Leena Suntornsuk and Keiichi Koizumi and Yurika Saitoh and Nakamura, {Eliane Shizuka} and Naparat Kammasud and Opa Vajaragupta and Ikuo Saiki",

year = "2004",

doi = "10.11339/jtm.21.94",

language = "英語",

volume = "21",

pages = "94--99",

journal = "Journal of Traditional Medicines",

issn = "1880-1447",

publisher = "Medical and Pharmaceutical Society for WAKAN-YAKU",

number = "2",

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TY - JOUR

T1 - Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex

AU - Suntornsuk, Leena

AU - Koizumi, Keiichi

AU - Saitoh, Yurika

AU - Nakamura, Eliane Shizuka

AU - Kammasud, Naparat

AU - Vajaragupta, Opa

AU - Saiki, Ikuo

PY - 2004

Y1 - 2004

N2 - We investigated the anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative (curcumin ED) and curcumin ethylenediamine manganese complex (curcumin EDMn) through the inhibition of the formation of tube-like structures by human umbilical vascular endothelial cells (HUVEC). Curcumin, curcumin ED, curcumin EDMn did not show cytotoxicity to HUVEC at concentrations equal and lower than 10 μM. At the concentration of 10 μM, curcumin, curcumin ED and curcumin EDMn inhibited the tube formation by approximately 94%, 40% and 65%, respectively. These results suggest that curcumin ED and curcumin EDMn might be useful as anti-angiogenic drugs in addition to their anti-lipid peroxidase and superoxide dismutase activities as described in our previous studies.

AB - We investigated the anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative (curcumin ED) and curcumin ethylenediamine manganese complex (curcumin EDMn) through the inhibition of the formation of tube-like structures by human umbilical vascular endothelial cells (HUVEC). Curcumin, curcumin ED, curcumin EDMn did not show cytotoxicity to HUVEC at concentrations equal and lower than 10 μM. At the concentration of 10 μM, curcumin, curcumin ED and curcumin EDMn inhibited the tube formation by approximately 94%, 40% and 65%, respectively. These results suggest that curcumin ED and curcumin EDMn might be useful as anti-angiogenic drugs in addition to their anti-lipid peroxidase and superoxide dismutase activities as described in our previous studies.

KW - angiogenesis

KW - cancer

KW - curcumin

KW - human umbilical vascular endothelial cell

KW - tube formation

UR - http://www.scopus.com/inward/record.url?scp=85009555963&partnerID=8YFLogxK

U2 - 10.11339/jtm.21.94

DO - 10.11339/jtm.21.94

M3 - 学術論文

AN - SCOPUS:85009555963

SN - 1880-1447

VL - 21

SP - 94

EP - 99

JO - Journal of Traditional Medicines

JF - Journal of Traditional Medicines

IS - 2

ER -

Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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