Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation

Suresh Awale; Eduardo M.N. Nakashima; Surya K. Kalauni; Yasuhiro Tezuka; Yukiko Kurashima; Jie Lu; Hiroyasu Esumi; Shigetoshi Kadota

doi:10.1016/j.bmcl.2005.10.046

Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation

Suresh Awale, Eduardo M.N. Nakashima, Surya K. Kalauni, Yasuhiro Tezuka, Yukiko Kurashima, Jie Lu, Hiroyasu Esumi, Shigetoshi Kadota^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

The CH₂Cl₂-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 μg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 μg/ml.

Original language	English
Pages (from-to)	581-583
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2005.10.046
State	Published - 2006/02/01

Keywords

Angelica pubescens
Angelmarin
Anti-austerity
Anti-cancer agent
PANC-1
Screening strategy

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2005.10.046

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@article{864a1994833149bb9c3dd054d77079ad,

title = "Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation",

abstract = "The CH2Cl2-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 μg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 μg/ml.",

keywords = "Angelica pubescens, Angelmarin, Anti-austerity, Anti-cancer agent, PANC-1, Screening strategy",

author = "Suresh Awale and Nakashima, {Eduardo M.N.} and Kalauni, {Surya K.} and Yasuhiro Tezuka and Yukiko Kurashima and Jie Lu and Hiroyasu Esumi and Shigetoshi Kadota",

note = "Funding Information: This work was supported in part by a grant from the Ministry of Health and Welfare for the Second-Term Comprehensive 10-year Strategy for Cancer Control and Grants-in-Aid for Cancer Research from the Ministry of Health and Welfare and the Ministry of Education, Science, Sports and Culture.",

year = "2006",

month = feb,

day = "1",

doi = "10.1016/j.bmcl.2005.10.046",

language = "英語",

volume = "16",

pages = "581--583",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "3",

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TY - JOUR

T1 - Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation

AU - Awale, Suresh

AU - Nakashima, Eduardo M.N.

AU - Kalauni, Surya K.

AU - Tezuka, Yasuhiro

AU - Kurashima, Yukiko

AU - Lu, Jie

AU - Esumi, Hiroyasu

AU - Kadota, Shigetoshi

N1 - Funding Information: This work was supported in part by a grant from the Ministry of Health and Welfare for the Second-Term Comprehensive 10-year Strategy for Cancer Control and Grants-in-Aid for Cancer Research from the Ministry of Health and Welfare and the Ministry of Education, Science, Sports and Culture.

PY - 2006/2/1

Y1 - 2006/2/1

N2 - The CH2Cl2-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 μg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 μg/ml.

AB - The CH2Cl2-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 μg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 μg/ml.

KW - Angelica pubescens

KW - Angelmarin

KW - Anti-austerity

KW - Anti-cancer agent

KW - PANC-1

KW - Screening strategy

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U2 - 10.1016/j.bmcl.2005.10.046

DO - 10.1016/j.bmcl.2005.10.046

M3 - 学術論文

C2 - 16288865

AN - SCOPUS:29544446440

SN - 0960-894X

VL - 16

SP - 581

EP - 583

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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