TY - JOUR
T1 - Amygdala and insula volumes prior to illness onset in bipolar disorder
T2 - A magnetic resonance imaging study
AU - Bechdolf, Andreas
AU - Wood, Stephen J.
AU - Nelson, Barnaby
AU - Velakoulis, Dennis
AU - Yücel, Murat
AU - Takahashi, Tsutomu
AU - Yung, Alison R.
AU - Berk, Michael
AU - Wong, Michael T.
AU - Pantelis, Christos
AU - McGorry, Patrick D.
N1 - Funding Information:
This study was supported by project grants from the National Health & Medical Research Council (NHMRC; grant IDs: 145627 , 145737 , 970598 , 981112 , 970391 ), NHMRC Program Grant (ID: 350241 ), and the Colonial Foundation . Dr Bechdolf was supported by a grant from the German Research Foundation (Be 3697/1-1). Prof. Wood was supported by a Clinical Career Development Award from the NHMRC (ID: 359223). Dr. Takahashi was supported to undertake this work by a Grant-in-Aid for Scientific Research (No. 19591346) from the Japanese Society for the Promotion of Science.
PY - 2012/1/30
Y1 - 2012/1/30
N2 - There are now numerous reports of neuroanatomical abnormalities in people with bipolar disorder. However, it remains unclear whether those abnormalities predate the onset of the illness. In this cross-sectional magnetic resonance imaging study, we assessed 11 young people clinically at ultra-high risk of development of psychosis (UHR), who all developed bipolar I or II disorder by follow-up (median time to onset 328. days - UHR-BP), 11 matched UHR participants, who had no psychiatric diagnosis after at least 12. months of follow-up (UHR-Well) and 11 matched healthy controls (HC). Our main outcome measures were amygdala, hippocampus, insula, lateral ventricular and whole brain volumes. Amygdala and insula volume reductions were more pronounced in the UHR-BP than in the UHR-Well and HC group. Lateral ventricle, whole-brain and hippocampal volumes did not differ between groups. If these findings are confirmed, they suggest that imaging investigations could help to distinguish people who will subsequently develop bipolar disorder from those who will not, at least in symptomatically enriched samples.
AB - There are now numerous reports of neuroanatomical abnormalities in people with bipolar disorder. However, it remains unclear whether those abnormalities predate the onset of the illness. In this cross-sectional magnetic resonance imaging study, we assessed 11 young people clinically at ultra-high risk of development of psychosis (UHR), who all developed bipolar I or II disorder by follow-up (median time to onset 328. days - UHR-BP), 11 matched UHR participants, who had no psychiatric diagnosis after at least 12. months of follow-up (UHR-Well) and 11 matched healthy controls (HC). Our main outcome measures were amygdala, hippocampus, insula, lateral ventricular and whole brain volumes. Amygdala and insula volume reductions were more pronounced in the UHR-BP than in the UHR-Well and HC group. Lateral ventricle, whole-brain and hippocampal volumes did not differ between groups. If these findings are confirmed, they suggest that imaging investigations could help to distinguish people who will subsequently develop bipolar disorder from those who will not, at least in symptomatically enriched samples.
KW - Amygdala
KW - At-risk mental state
KW - Bipolar affective disorder
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=84862820880&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2011.06.010
DO - 10.1016/j.pscychresns.2011.06.010
M3 - 学術論文
C2 - 22281200
AN - SCOPUS:84862820880
SN - 0925-4927
VL - 201
SP - 34
EP - 39
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 1
ER -
