Abstract
In order to find antiosteoporotic agents from natural resources, 32 Indonesian medicinal plants were screened for their effects on osteoblast differentiation by using alkaline phosphatase (ALP) activity in MC3T3-E1 osteoblast cells as a marker. From the extract of Barleria lupulina, which showed the most potent activity, 13 iridoid glucosides, including three new ones [8-O-acetylipolamiidic acid (1), 8-O-acetyl-6-O-(p-methoxy-cis-cinnamoyl) shanzhiside (2), and 8-O-acetyl-6-O-(p-methoxy-transcinnamoyl) shanzhiside (3)] were identified. Among the 13 iridoid glucosides, ipolamiide (4) showed the most potent activity in a dose-dependent manner.
| Original language | English |
|---|---|
| Pages (from-to) | 1711-1716 |
| Number of pages | 6 |
| Journal | Natural Product Communications |
| Volume | 5 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2010 |
Keywords
- Acanthaceae
- Alkaline phosphatase (ALP)
- Barleria lupulina
- Iridoid glucosides
- Landik
- MC3T3-E1 cells
ASJC Scopus subject areas
- Pharmacology
- Plant Science
- Drug Discovery
- Complementary and alternative medicine