Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss

M. Nemoto; Y. Morita; Y. Mishima; S. Takahashi; T. Nomura; T. Ushiki; T. Shiroishi; Y. Kikkawa; H. Yonekawa; R. Kominami

doi:10.1016/j.bbrc.2004.09.186

Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss

M. Nemoto, Y. Morita, Y. Mishima, S. Takahashi, T. Nomura, T. Ushiki, T. Shiroishi, Y. Kikkawa, H. Yonekawa, R. Kominami^*

^*Corresponding author for this work

Otorhinolaryngology-Head and Neck Surgery

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Genetic variation in humans probably plays a role in determining the range of individual susceptibility to age-related hearing loss (AHL), but no contributing loci have been identified because of the difficulties of dissecting complex traits in humans. This paper reports mapping of an AHL locus using a panel of consomic mice between C57BL/6J (B6) and MSM strains, which covered more than a half of chromosome sets. B6 strain exhibited AHL beginning at 10 months of age whereas MSM strain, derived from Japanese wild mice, had normal hearing throughout life. Individuals in the panel were examined with auditory brainstem response (ABR) at various months of age, revealing that one particular strain (B6-Chr17^MSM) substituting the chromosome 17 with the MSM-derived one showed a prominent resistance, having still good hearing at 18 months of age. Subsequent mapping using 89 individuals in the cross between B6-Chr17 ^MSM and B6 was performed, which showed a significant association of ABR thresholds with loci in the vicinity of D17Mit119. These results show a novel AHL-resistant locus, designated as Ahl3, on the chromosome 17.

Original language	English
Pages (from-to)	1283-1288
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	324
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2004.09.186
State	Published - 2004/11/26

Keywords

ABR
Age-related hearing loss
Consomic strain
Genetic mapping
QTL

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2004.09.186

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title = "Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss",

abstract = "Genetic variation in humans probably plays a role in determining the range of individual susceptibility to age-related hearing loss (AHL), but no contributing loci have been identified because of the difficulties of dissecting complex traits in humans. This paper reports mapping of an AHL locus using a panel of consomic mice between C57BL/6J (B6) and MSM strains, which covered more than a half of chromosome sets. B6 strain exhibited AHL beginning at 10 months of age whereas MSM strain, derived from Japanese wild mice, had normal hearing throughout life. Individuals in the panel were examined with auditory brainstem response (ABR) at various months of age, revealing that one particular strain (B6-Chr17MSM) substituting the chromosome 17 with the MSM-derived one showed a prominent resistance, having still good hearing at 18 months of age. Subsequent mapping using 89 individuals in the cross between B6-Chr17 MSM and B6 was performed, which showed a significant association of ABR thresholds with loci in the vicinity of D17Mit119. These results show a novel AHL-resistant locus, designated as Ahl3, on the chromosome 17.",

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author = "M. Nemoto and Y. Morita and Y. Mishima and S. Takahashi and T. Nomura and T. Ushiki and T. Shiroishi and Y. Kikkawa and H. Yonekawa and R. Kominami",

note = "Funding Information: This work was supported by Grants-in-Aid from the Ministry of Culture, Education and Sports, Science and Technology of Japan. ",

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T1 - Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss

AU - Nemoto, M.

AU - Morita, Y.

AU - Mishima, Y.

AU - Takahashi, S.

AU - Nomura, T.

AU - Ushiki, T.

AU - Shiroishi, T.

AU - Kikkawa, Y.

AU - Yonekawa, H.

AU - Kominami, R.

N1 - Funding Information: This work was supported by Grants-in-Aid from the Ministry of Culture, Education and Sports, Science and Technology of Japan.

PY - 2004/11/26

Y1 - 2004/11/26

N2 - Genetic variation in humans probably plays a role in determining the range of individual susceptibility to age-related hearing loss (AHL), but no contributing loci have been identified because of the difficulties of dissecting complex traits in humans. This paper reports mapping of an AHL locus using a panel of consomic mice between C57BL/6J (B6) and MSM strains, which covered more than a half of chromosome sets. B6 strain exhibited AHL beginning at 10 months of age whereas MSM strain, derived from Japanese wild mice, had normal hearing throughout life. Individuals in the panel were examined with auditory brainstem response (ABR) at various months of age, revealing that one particular strain (B6-Chr17MSM) substituting the chromosome 17 with the MSM-derived one showed a prominent resistance, having still good hearing at 18 months of age. Subsequent mapping using 89 individuals in the cross between B6-Chr17 MSM and B6 was performed, which showed a significant association of ABR thresholds with loci in the vicinity of D17Mit119. These results show a novel AHL-resistant locus, designated as Ahl3, on the chromosome 17.

AB - Genetic variation in humans probably plays a role in determining the range of individual susceptibility to age-related hearing loss (AHL), but no contributing loci have been identified because of the difficulties of dissecting complex traits in humans. This paper reports mapping of an AHL locus using a panel of consomic mice between C57BL/6J (B6) and MSM strains, which covered more than a half of chromosome sets. B6 strain exhibited AHL beginning at 10 months of age whereas MSM strain, derived from Japanese wild mice, had normal hearing throughout life. Individuals in the panel were examined with auditory brainstem response (ABR) at various months of age, revealing that one particular strain (B6-Chr17MSM) substituting the chromosome 17 with the MSM-derived one showed a prominent resistance, having still good hearing at 18 months of age. Subsequent mapping using 89 individuals in the cross between B6-Chr17 MSM and B6 was performed, which showed a significant association of ABR thresholds with loci in the vicinity of D17Mit119. These results show a novel AHL-resistant locus, designated as Ahl3, on the chromosome 17.

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Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss

Abstract

Keywords

ASJC Scopus subject areas

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