Administration of corticosterone alters intracellular localization of brain-derived neurotrophic factor-like immunoreactivity in the rat brain

Atsumi Nitta; Hidefumi Fukumitsu; Hiroshige Kataoka; Hiroshi Nomoto; Shoei Furukawa

doi:10.1016/S0304-3940(97)00256-5

Administration of corticosterone alters intracellular localization of brain-derived neurotrophic factor-like immunoreactivity in the rat brain

Atsumi Nitta, Hidefumi Fukumitsu, Hiroshige Kataoka, Hiroshi Nomoto, Shoei Furukawa^*

^*Corresponding author for this work

Pharmaceutical Therapy and Neuropharmacology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We investigated the distribution of immunoreactivity for brain-derived neurotrophic factor (BDNF) in rat brain after peripheral administration of corticosterone or vehicle. In the immunohistochemical study, BDNF-like immunoreactivity (LI) was observed predominantly in the nucleus of the cortical and hippocampal neurons in the brain of vehicle-treated rats. In corticosterone-treated rats, BDNF-LI was markedly reduced in the nucleus and concomitantly increased in cytoplasm. Western immunoblot study also demonstrated that corticosterone significantly reduced BDNF-LI in the nuclear fraction of the cerebral cortex and hippocampus. These results indicate that corticostrone regulates the intracellular localization of BDNF and/or its derivatives in the rat brain.

Original language	English
Pages (from-to)	115-118
Number of pages	4
Journal	Neuroscience Letters
Volume	226
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(97)00256-5
State	Published - 1997/04/25

Keywords

Brain-derived neurotrophic factor (BDNF)
Corticosterone
Glucocorticoid
Immunohistochemistry
Neurotrophin
Rats

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(97)00256-5

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title = "Administration of corticosterone alters intracellular localization of brain-derived neurotrophic factor-like immunoreactivity in the rat brain",

abstract = "We investigated the distribution of immunoreactivity for brain-derived neurotrophic factor (BDNF) in rat brain after peripheral administration of corticosterone or vehicle. In the immunohistochemical study, BDNF-like immunoreactivity (LI) was observed predominantly in the nucleus of the cortical and hippocampal neurons in the brain of vehicle-treated rats. In corticosterone-treated rats, BDNF-LI was markedly reduced in the nucleus and concomitantly increased in cytoplasm. Western immunoblot study also demonstrated that corticosterone significantly reduced BDNF-LI in the nuclear fraction of the cerebral cortex and hippocampus. These results indicate that corticostrone regulates the intracellular localization of BDNF and/or its derivatives in the rat brain.",

keywords = "Brain-derived neurotrophic factor (BDNF), Corticosterone, Glucocorticoid, Immunohistochemistry, Neurotrophin, Rats",

author = "Atsumi Nitta and Hidefumi Fukumitsu and Hiroshige Kataoka and Hiroshi Nomoto and Shoei Furukawa",

note = "Funding Information: This work was supported, in part, by a grant-in-aid from the program Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, and Culture of Japan.",

year = "1997",

month = apr,

day = "25",

doi = "10.1016/S0304-3940(97)00256-5",

language = "英語",

volume = "226",

pages = "115--118",

journal = "Neuroscience Letters",

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T1 - Administration of corticosterone alters intracellular localization of brain-derived neurotrophic factor-like immunoreactivity in the rat brain

AU - Nitta, Atsumi

AU - Fukumitsu, Hidefumi

AU - Kataoka, Hiroshige

AU - Nomoto, Hiroshi

AU - Furukawa, Shoei

N1 - Funding Information: This work was supported, in part, by a grant-in-aid from the program Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, and Culture of Japan.

PY - 1997/4/25

Y1 - 1997/4/25

N2 - We investigated the distribution of immunoreactivity for brain-derived neurotrophic factor (BDNF) in rat brain after peripheral administration of corticosterone or vehicle. In the immunohistochemical study, BDNF-like immunoreactivity (LI) was observed predominantly in the nucleus of the cortical and hippocampal neurons in the brain of vehicle-treated rats. In corticosterone-treated rats, BDNF-LI was markedly reduced in the nucleus and concomitantly increased in cytoplasm. Western immunoblot study also demonstrated that corticosterone significantly reduced BDNF-LI in the nuclear fraction of the cerebral cortex and hippocampus. These results indicate that corticostrone regulates the intracellular localization of BDNF and/or its derivatives in the rat brain.

AB - We investigated the distribution of immunoreactivity for brain-derived neurotrophic factor (BDNF) in rat brain after peripheral administration of corticosterone or vehicle. In the immunohistochemical study, BDNF-like immunoreactivity (LI) was observed predominantly in the nucleus of the cortical and hippocampal neurons in the brain of vehicle-treated rats. In corticosterone-treated rats, BDNF-LI was markedly reduced in the nucleus and concomitantly increased in cytoplasm. Western immunoblot study also demonstrated that corticosterone significantly reduced BDNF-LI in the nuclear fraction of the cerebral cortex and hippocampus. These results indicate that corticostrone regulates the intracellular localization of BDNF and/or its derivatives in the rat brain.

KW - Brain-derived neurotrophic factor (BDNF)

KW - Corticosterone

KW - Glucocorticoid

KW - Immunohistochemistry

KW - Neurotrophin

KW - Rats

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U2 - 10.1016/S0304-3940(97)00256-5

DO - 10.1016/S0304-3940(97)00256-5

M3 - 学術論文

C2 - 9159503

AN - SCOPUS:0030929825

SN - 0304-3940

VL - 226

SP - 115

EP - 118

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Administration of corticosterone alters intracellular localization of brain-derived neurotrophic factor-like immunoreactivity in the rat brain

Abstract

Keywords

ASJC Scopus subject areas

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