Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ25-35-Induced Axonal Atrophy

Zhi You Yang, Tomoharu Kuboyama, Kohei Kazuma, Katsuhiro Konno, Chihiro Tohda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Axonal regeneration might contribute to the restoration of damaged neuronal networks and improvement of memory deficits in a murine Alzheimers disease (AD) model. A search for axonal regenerative drugs was performed to discover novel therapeutic options for AD. In this study, an aqueous extract of Drynaria fortunei rhizomes reversed Aβ25-35-induced axonal atrophy in cultured cortical neurons of mice. Bioassay-guided fractionation of this extract led to the isolation and identification of compounds 1-5. Among them, (2S)-neoeriocitrin (2) and caffeic acid 4-O-glucoside (4) showed significant axonal elongation effects on Aβ25-35-induced atrophy.

Original languageEnglish
Pages (from-to)2297-2300
Number of pages4
JournalJournal of Natural Products
Volume78
Issue number9
DOIs
StatePublished - 2015/09/25

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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