Activation of protein kinase C from guinea‐pig and rat ventricular muscles by musclide‐A1 and its (2R, 5S)‐diastereomer

Ikuko Kimura*, Yusaku Takamura, Teruko Uwano, Yukiko Hata, Masayasu Kimura, Tohru Kikuchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The activating effects of musclide‐A1, 6‐methyl‐2,5‐heptanediol 5‐(hydrogen sulphate) (la), and its (2R, 5S)‐ and (2R, 5R)‐diastereomers on ventricular protein kinase C from guinea‐pig and rat were compared with other natural compounds derived from musk and non‐natural related compounds. The (2R, 5S)‐diastereomer was most potent among musk‐derived compounds and its related non‐natural compounds. The activation by la (20 μM) was produced in the presence of low [Ca2+]0 and phosphatidylserine like 1,2‐dioctanoylglycerol (2 μM). The activation pattern for peaks eluted by a hydroxyapatite column demonstrated that 1a activates ventricular‐specific protein kinase C peak II, suggesting one mechanism for the beta‐adrenergic cardiotonic potentiation by 1a.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalPhytotherapy Research
Volume9
Issue number1
DOIs
StatePublished - 1995/02

Keywords

  • (2R, 5S)‐diastereomer
  • 1,2‐dioctanoyl glycerol
  • musclide‐A1
  • ventricular protein kinase C

ASJC Scopus subject areas

  • Pharmacology

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