TY - JOUR
T1 - Activation of protein kinase C from guinea‐pig and rat ventricular muscles by musclide‐A1 and its (2R, 5S)‐diastereomer
AU - Kimura, Ikuko
AU - Takamura, Yusaku
AU - Uwano, Teruko
AU - Hata, Yukiko
AU - Kimura, Masayasu
AU - Kikuchi, Tohru
PY - 1995/2
Y1 - 1995/2
N2 - The activating effects of musclide‐A1, 6‐methyl‐2,5‐heptanediol 5‐(hydrogen sulphate) (la), and its (2R, 5S)‐ and (2R, 5R)‐diastereomers on ventricular protein kinase C from guinea‐pig and rat were compared with other natural compounds derived from musk and non‐natural related compounds. The (2R, 5S)‐diastereomer was most potent among musk‐derived compounds and its related non‐natural compounds. The activation by la (20 μM) was produced in the presence of low [Ca2+]0 and phosphatidylserine like 1,2‐dioctanoylglycerol (2 μM). The activation pattern for peaks eluted by a hydroxyapatite column demonstrated that 1a activates ventricular‐specific protein kinase C peak II, suggesting one mechanism for the beta‐adrenergic cardiotonic potentiation by 1a.
AB - The activating effects of musclide‐A1, 6‐methyl‐2,5‐heptanediol 5‐(hydrogen sulphate) (la), and its (2R, 5S)‐ and (2R, 5R)‐diastereomers on ventricular protein kinase C from guinea‐pig and rat were compared with other natural compounds derived from musk and non‐natural related compounds. The (2R, 5S)‐diastereomer was most potent among musk‐derived compounds and its related non‐natural compounds. The activation by la (20 μM) was produced in the presence of low [Ca2+]0 and phosphatidylserine like 1,2‐dioctanoylglycerol (2 μM). The activation pattern for peaks eluted by a hydroxyapatite column demonstrated that 1a activates ventricular‐specific protein kinase C peak II, suggesting one mechanism for the beta‐adrenergic cardiotonic potentiation by 1a.
KW - (2R, 5S)‐diastereomer
KW - 1,2‐dioctanoyl glycerol
KW - musclide‐A1
KW - ventricular protein kinase C
UR - http://www.scopus.com/inward/record.url?scp=0028852418&partnerID=8YFLogxK
U2 - 10.1002/ptr.2650090105
DO - 10.1002/ptr.2650090105
M3 - 学術論文
AN - SCOPUS:0028852418
SN - 0951-418X
VL - 9
SP - 16
EP - 20
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 1
ER -