Abnormal serum lysophospholipids in multiple myeloma patients

Takayo Sasagawa; Misako Okita; Jun Murakami; Tsutomu Kato; Akiharu Watanabe

doi:10.1007/s11745-999-332-5

Abnormal serum lysophospholipids in multiple myeloma patients

Takayo Sasagawa^*, Misako Okita, Jun Murakami, Tsutomu Kato, Akiharu Watanabe

^*Corresponding author for this work

Clinical Laboratory and Transfusion Medicine & Cell Therapy Center

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA) mediate various kinds of biological activities and play an important role in cellular signal transduction. We analyzed serum phospholipids obtained from 16 multiple myeloma (MM) patients and observed that serum LPA level was significantly higher in MM patients (5.3 ± 0.5 nmol/mL) than in normal controls (1.7 ± 0.3 nmol/mL). LPC level was also higher than that in normal controls, and it correlated significantly with the concentration of LPA (r = 0.678, P < 0.01). In MM patients, palmitic acid/linoleic acid ratios in phosphatidylcholine and LPC were higher than those in normal controls. In the 12-mon follow-up study of two patients with the immune globulin G type, we recognized that the increase of LPC, LPA, and arachidonic acid/linoleic acid ratio in phosphatidylinositol corresponded with a decline in the serum albumin level and choline esterase activity.

Original language	English
Pages (from-to)	17-21
Number of pages	5
Journal	Lipids
Volume	34
Issue number	1
DOIs	https://doi.org/10.1007/s11745-999-332-5
State	Published - 1999

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Cell Biology

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title = "Abnormal serum lysophospholipids in multiple myeloma patients",

abstract = "Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA) mediate various kinds of biological activities and play an important role in cellular signal transduction. We analyzed serum phospholipids obtained from 16 multiple myeloma (MM) patients and observed that serum LPA level was significantly higher in MM patients (5.3 ± 0.5 nmol/mL) than in normal controls (1.7 ± 0.3 nmol/mL). LPC level was also higher than that in normal controls, and it correlated significantly with the concentration of LPA (r = 0.678, P < 0.01). In MM patients, palmitic acid/linoleic acid ratios in phosphatidylcholine and LPC were higher than those in normal controls. In the 12-mon follow-up study of two patients with the immune globulin G type, we recognized that the increase of LPC, LPA, and arachidonic acid/linoleic acid ratio in phosphatidylinositol corresponded with a decline in the serum albumin level and choline esterase activity.",

author = "Takayo Sasagawa and Misako Okita and Jun Murakami and Tsutomu Kato and Akiharu Watanabe",

year = "1999",

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T1 - Abnormal serum lysophospholipids in multiple myeloma patients

AU - Sasagawa, Takayo

AU - Okita, Misako

AU - Murakami, Jun

AU - Kato, Tsutomu

AU - Watanabe, Akiharu

PY - 1999

Y1 - 1999

N2 - Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA) mediate various kinds of biological activities and play an important role in cellular signal transduction. We analyzed serum phospholipids obtained from 16 multiple myeloma (MM) patients and observed that serum LPA level was significantly higher in MM patients (5.3 ± 0.5 nmol/mL) than in normal controls (1.7 ± 0.3 nmol/mL). LPC level was also higher than that in normal controls, and it correlated significantly with the concentration of LPA (r = 0.678, P < 0.01). In MM patients, palmitic acid/linoleic acid ratios in phosphatidylcholine and LPC were higher than those in normal controls. In the 12-mon follow-up study of two patients with the immune globulin G type, we recognized that the increase of LPC, LPA, and arachidonic acid/linoleic acid ratio in phosphatidylinositol corresponded with a decline in the serum albumin level and choline esterase activity.

AB - Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA) mediate various kinds of biological activities and play an important role in cellular signal transduction. We analyzed serum phospholipids obtained from 16 multiple myeloma (MM) patients and observed that serum LPA level was significantly higher in MM patients (5.3 ± 0.5 nmol/mL) than in normal controls (1.7 ± 0.3 nmol/mL). LPC level was also higher than that in normal controls, and it correlated significantly with the concentration of LPA (r = 0.678, P < 0.01). In MM patients, palmitic acid/linoleic acid ratios in phosphatidylcholine and LPC were higher than those in normal controls. In the 12-mon follow-up study of two patients with the immune globulin G type, we recognized that the increase of LPC, LPA, and arachidonic acid/linoleic acid ratio in phosphatidylinositol corresponded with a decline in the serum albumin level and choline esterase activity.

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Abnormal serum lysophospholipids in multiple myeloma patients

Abstract

ASJC Scopus subject areas

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