Abnormal serum lysophospholipids in multiple myeloma patients

Takayo Sasagawa*, Misako Okita, Jun Murakami, Tsutomu Kato, Akiharu Watanabe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA) mediate various kinds of biological activities and play an important role in cellular signal transduction. We analyzed serum phospholipids obtained from 16 multiple myeloma (MM) patients and observed that serum LPA level was significantly higher in MM patients (5.3 ± 0.5 nmol/mL) than in normal controls (1.7 ± 0.3 nmol/mL). LPC level was also higher than that in normal controls, and it correlated significantly with the concentration of LPA (r = 0.678, P < 0.01). In MM patients, palmitic acid/linoleic acid ratios in phosphatidylcholine and LPC were higher than those in normal controls. In the 12-mon follow-up study of two patients with the immune globulin G type, we recognized that the increase of LPC, LPA, and arachidonic acid/linoleic acid ratio in phosphatidylinositol corresponded with a decline in the serum albumin level and choline esterase activity.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalLipids
Volume34
Issue number1
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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