A single spike deteriorates synaptic conductance estimation

Ryota Kobayashi; Hiroshi Nishimaru; Hisao Nishijo; Petr Lansky

doi:10.1016/j.biosystems.2017.07.007

A single spike deteriorates synaptic conductance estimation

Ryota Kobayashi^*, Hiroshi Nishimaru, Hisao Nishijo, Petr Lansky

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We investigated the estimation accuracy of synaptic conductances by analyzing simulated voltage traces generated by a Hodgkin–Huxley type model. We show that even a single spike substantially deteriorates the estimation. We also demonstrate that two approaches, namely, negative current injection and spike removal, can ameliorate this deterioration.

Original language	English
Pages (from-to)	41-45
Number of pages	5
Journal	BioSystems
Volume	161
DOIs	https://doi.org/10.1016/j.biosystems.2017.07.007
State	Published - 2017/11

Keywords

Ornstein–Uhlenbeck process
Single neuron models
Synaptic conductance estimation

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
Applied Mathematics

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10.1016/j.biosystems.2017.07.007

Cite this

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title = "A single spike deteriorates synaptic conductance estimation",

abstract = "We investigated the estimation accuracy of synaptic conductances by analyzing simulated voltage traces generated by a Hodgkin–Huxley type model. We show that even a single spike substantially deteriorates the estimation. We also demonstrate that two approaches, namely, negative current injection and spike removal, can ameliorate this deterioration.",

keywords = "Ornstein–Uhlenbeck process, Single neuron models, Synaptic conductance estimation",

author = "Ryota Kobayashi and Hiroshi Nishimaru and Hisao Nishijo and Petr Lansky",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = nov,

doi = "10.1016/j.biosystems.2017.07.007",

language = "英語",

volume = "161",

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T1 - A single spike deteriorates synaptic conductance estimation

AU - Kobayashi, Ryota

AU - Nishimaru, Hiroshi

AU - Nishijo, Hisao

AU - Lansky, Petr

PY - 2017/11

Y1 - 2017/11

N2 - We investigated the estimation accuracy of synaptic conductances by analyzing simulated voltage traces generated by a Hodgkin–Huxley type model. We show that even a single spike substantially deteriorates the estimation. We also demonstrate that two approaches, namely, negative current injection and spike removal, can ameliorate this deterioration.

AB - We investigated the estimation accuracy of synaptic conductances by analyzing simulated voltage traces generated by a Hodgkin–Huxley type model. We show that even a single spike substantially deteriorates the estimation. We also demonstrate that two approaches, namely, negative current injection and spike removal, can ameliorate this deterioration.

KW - Ornstein–Uhlenbeck process

KW - Single neuron models

KW - Synaptic conductance estimation

UR - http://www.scopus.com/inward/record.url?scp=85028336271&partnerID=8YFLogxK

U2 - 10.1016/j.biosystems.2017.07.007

DO - 10.1016/j.biosystems.2017.07.007

M3 - 学術論文

C2 - 28756162

AN - SCOPUS:85028336271

SN - 0303-2647

VL - 161

SP - 41

EP - 45

JO - BioSystems

JF - BioSystems

ER -

A single spike deteriorates synaptic conductance estimation

Abstract

Keywords

ASJC Scopus subject areas

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