TY - JOUR
T1 - A simple and efficient radical reduction using water-soluble radical initiator and hypophosphorous acid in aqueous alcohol
AU - Nambu, Hisanori
AU - Alinejad, Anahita Hessamian
AU - Hata, Kayoko
AU - Fujioka, Hiromichi
AU - Kita, Yasuyuki
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research (S) (No. 7690) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. We thank Wako Pure Chemical Industries, Ltd, for the generous supply of several water-soluble azo-type initiators. H.N. and A.H.A. thank the Japan Society for the Promotion of Science (JSPS) for their postdoctoral fellowships.
PY - 2004/11/22
Y1 - 2004/11/22
N2 - A simple, mild and high-yielding procedure for the reduction of various halogenated compounds using a combination of the water-soluble radical initiater (VA-061), hypophosphorous acid and triethylamine in aqueous alcohol is reported. A simple, mild, and high-yielding procedure for the reduction of various halogenated compounds using a combination of the water-soluble radical initiator, 2,2′-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), a water-soluble chain carrier, hypophosphorous acid, and the base, triethylamine, in aqueous alcohol is described. The reagents used in this method are all water soluble, and therefore, an almost pure desired product can be readily obtained using only an extraction procedure.
AB - A simple, mild and high-yielding procedure for the reduction of various halogenated compounds using a combination of the water-soluble radical initiater (VA-061), hypophosphorous acid and triethylamine in aqueous alcohol is reported. A simple, mild, and high-yielding procedure for the reduction of various halogenated compounds using a combination of the water-soluble radical initiator, 2,2′-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), a water-soluble chain carrier, hypophosphorous acid, and the base, triethylamine, in aqueous alcohol is described. The reagents used in this method are all water soluble, and therefore, an almost pure desired product can be readily obtained using only an extraction procedure.
KW - Aqueous alcohol
KW - Hypophosphorous acid
KW - Radical reduction
KW - The water-soluble radical initiator
UR - http://www.scopus.com/inward/record.url?scp=7444251533&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2004.09.130
DO - 10.1016/j.tetlet.2004.09.130
M3 - 学術論文
AN - SCOPUS:7444251533
SN - 0040-4039
VL - 45
SP - 8927
EP - 8929
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 48
ER -