A Parkinson’s disease patient displaying increased neuromelanin-sensitive areas in the substantia nigra after rehabilitation with tDCS: a case report

Koji Ishikuro; Noriaki Hattori; Rieko Imanishi; Kohta Furuya; Takeshi Nakata; Nobuhiro Dougu; Mamoru Yamamoto; Hirofumi Konishi; Takamasa Nukui; Tomohiro Hayashi; Ryoko Anada; Noriyuki Matsuda; Hiroaki Hirosawa; Ryo Tanaka; Takashi Shibata; Koichi Mori; Kyo Noguchi; Satoshi Kuroda; Yuji Nakatsuji; Hisao Nishijo

doi:10.1080/13554794.2021.1975768

A Parkinson’s disease patient displaying increased neuromelanin-sensitive areas in the substantia nigra after rehabilitation with tDCS: a case report

Koji Ishikuro, Noriaki Hattori, Rieko Imanishi, Kohta Furuya, Takeshi Nakata, Nobuhiro Dougu, Mamoru Yamamoto, Hirofumi Konishi, Takamasa Nukui, Tomohiro Hayashi, Ryoko Anada, Noriyuki Matsuda, Hiroaki Hirosawa, Ryo Tanaka, Takashi Shibata, Koichi Mori, Kyo Noguchi, Satoshi Kuroda, Yuji Nakatsuji, Hisao Nishijo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Previous studies have reported that transcranial direct current stimulation (tDCS) of the frontal polar area (FPA) ameliorated motor disability in patients with Parkinson’s disease (PD). Here we report changes in neuromelanin (NM) imaging of dopaminergic neurons before and after rehabilitation combined with anodal tDCS over the FPA for 2 weeks in a PD patient. After the intervention, the patient showed clinically meaningful improvements while the NM-sensitive area in the SN increased by 18.8%. This case study is the first report of NM imaging of the SN in a PD patient who received tDCS. Abbreviations FPA: front polar area; PD: Parkinson’s disease; NM: neuromelanin; DCI: DOPA decarboxylase inhibitor; STEF: simple test for evaluating hand function; TUG: timed up and go test; TMT: trail-making test; SN: substantia nigra; NM-MRI: neuromelanin magnetic resonance imaging; MCID: the minimal clinically important difference; SNpc: substantia nigra pars compacta; VTA: ventral tegmental area; LC: locus coeruleus; PFC: prefrontal cortex; M1: primary motor cortex; MDS: Movement Disorder Society; MIBG: ¹²³I-metaiodobenzylguanidine; SBR: specific binding ratio; SPECT: single-photon emission computed tomography; DAT: dopamine transporter; NIBS: noninvasive brain stimulation; tDCS: transcranial direct current stimulation; MAOB: monoamine oxidase B; DCI: decarboxylase inhibitor; repetitive transcranial magnetic stimulation: rTMS; diffusion tensor imaging: DTI; arterial spin labeling: ASL.

Original language	English
Pages (from-to)	407-414
Number of pages	8
Journal	Neurocase
Volume	27
Issue number	5
DOIs	https://doi.org/10.1080/13554794.2021.1975768
State	Published - 2021

Keywords

NM-MRI
Parkinson’s disease
neuro-rehabilitation
substantia nigra
tDCS

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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10.1080/13554794.2021.1975768

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Ishikuro, K., Hattori, N., Imanishi, R., Furuya, K., Nakata, T., Dougu, N., Yamamoto, M., Konishi, H., Nukui, T., Hayashi, T., Anada, R., Matsuda, N., Hirosawa, H., Tanaka, R., Shibata, T., Mori, K., Noguchi, K., Kuroda, S., Nakatsuji, Y., & Nishijo, H. (2021). A Parkinson’s disease patient displaying increased neuromelanin-sensitive areas in the substantia nigra after rehabilitation with tDCS: a case report. Neurocase, 27(5), 407-414. https://doi.org/10.1080/13554794.2021.1975768

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title = "A Parkinson{\textquoteright}s disease patient displaying increased neuromelanin-sensitive areas in the substantia nigra after rehabilitation with tDCS: a case report",

abstract = "Previous studies have reported that transcranial direct current stimulation (tDCS) of the frontal polar area (FPA) ameliorated motor disability in patients with Parkinson{\textquoteright}s disease (PD). Here we report changes in neuromelanin (NM) imaging of dopaminergic neurons before and after rehabilitation combined with anodal tDCS over the FPA for 2 weeks in a PD patient. After the intervention, the patient showed clinically meaningful improvements while the NM-sensitive area in the SN increased by 18.8%. This case study is the first report of NM imaging of the SN in a PD patient who received tDCS. Abbreviations FPA: front polar area; PD: Parkinson{\textquoteright}s disease; NM: neuromelanin; DCI: DOPA decarboxylase inhibitor; STEF: simple test for evaluating hand function; TUG: timed up and go test; TMT: trail-making test; SN: substantia nigra; NM-MRI: neuromelanin magnetic resonance imaging; MCID: the minimal clinically important difference; SNpc: substantia nigra pars compacta; VTA: ventral tegmental area; LC: locus coeruleus; PFC: prefrontal cortex; M1: primary motor cortex; MDS: Movement Disorder Society; MIBG: 123I-metaiodobenzylguanidine; SBR: specific binding ratio; SPECT: single-photon emission computed tomography; DAT: dopamine transporter; NIBS: noninvasive brain stimulation; tDCS: transcranial direct current stimulation; MAOB: monoamine oxidase B; DCI: decarboxylase inhibitor; repetitive transcranial magnetic stimulation: rTMS; diffusion tensor imaging: DTI; arterial spin labeling: ASL.",

keywords = "NM-MRI, Parkinson{\textquoteright}s disease, neuro-rehabilitation, substantia nigra, tDCS",

author = "Koji Ishikuro and Noriaki Hattori and Rieko Imanishi and Kohta Furuya and Takeshi Nakata and Nobuhiro Dougu and Mamoru Yamamoto and Hirofumi Konishi and Takamasa Nukui and Tomohiro Hayashi and Ryoko Anada and Noriyuki Matsuda and Hiroaki Hirosawa and Ryo Tanaka and Takashi Shibata and Koichi Mori and Kyo Noguchi and Satoshi Kuroda and Yuji Nakatsuji and Hisao Nishijo",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

doi = "10.1080/13554794.2021.1975768",

language = "英語",

volume = "27",

pages = "407--414",

journal = "Neurocase",

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number = "5",

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Ishikuro, K, Hattori, N, Imanishi, R, Furuya, K, Nakata, T, Dougu, N, Yamamoto, M, Konishi, H, Nukui, T , Hayashi, T, Anada, R, Matsuda, N, Hirosawa, H , Tanaka, R, Shibata, T, Mori, K, Noguchi, K , Kuroda, S, Nakatsuji, Y & Nishijo, H 2021, 'A Parkinson’s disease patient displaying increased neuromelanin-sensitive areas in the substantia nigra after rehabilitation with tDCS: a case report', Neurocase, vol. 27, no. 5, pp. 407-414. https://doi.org/10.1080/13554794.2021.1975768

TY - JOUR

T1 - A Parkinson’s disease patient displaying increased neuromelanin-sensitive areas in the substantia nigra after rehabilitation with tDCS

T2 - a case report

AU - Ishikuro, Koji

AU - Hattori, Noriaki

AU - Imanishi, Rieko

AU - Furuya, Kohta

AU - Nakata, Takeshi

AU - Dougu, Nobuhiro

AU - Yamamoto, Mamoru

AU - Konishi, Hirofumi

AU - Nukui, Takamasa

AU - Hayashi, Tomohiro

AU - Anada, Ryoko

AU - Matsuda, Noriyuki

AU - Hirosawa, Hiroaki

AU - Tanaka, Ryo

AU - Shibata, Takashi

AU - Mori, Koichi

AU - Noguchi, Kyo

AU - Kuroda, Satoshi

AU - Nakatsuji, Yuji

AU - Nishijo, Hisao

PY - 2021

Y1 - 2021

N2 - Previous studies have reported that transcranial direct current stimulation (tDCS) of the frontal polar area (FPA) ameliorated motor disability in patients with Parkinson’s disease (PD). Here we report changes in neuromelanin (NM) imaging of dopaminergic neurons before and after rehabilitation combined with anodal tDCS over the FPA for 2 weeks in a PD patient. After the intervention, the patient showed clinically meaningful improvements while the NM-sensitive area in the SN increased by 18.8%. This case study is the first report of NM imaging of the SN in a PD patient who received tDCS. Abbreviations FPA: front polar area; PD: Parkinson’s disease; NM: neuromelanin; DCI: DOPA decarboxylase inhibitor; STEF: simple test for evaluating hand function; TUG: timed up and go test; TMT: trail-making test; SN: substantia nigra; NM-MRI: neuromelanin magnetic resonance imaging; MCID: the minimal clinically important difference; SNpc: substantia nigra pars compacta; VTA: ventral tegmental area; LC: locus coeruleus; PFC: prefrontal cortex; M1: primary motor cortex; MDS: Movement Disorder Society; MIBG: 123I-metaiodobenzylguanidine; SBR: specific binding ratio; SPECT: single-photon emission computed tomography; DAT: dopamine transporter; NIBS: noninvasive brain stimulation; tDCS: transcranial direct current stimulation; MAOB: monoamine oxidase B; DCI: decarboxylase inhibitor; repetitive transcranial magnetic stimulation: rTMS; diffusion tensor imaging: DTI; arterial spin labeling: ASL.

AB - Previous studies have reported that transcranial direct current stimulation (tDCS) of the frontal polar area (FPA) ameliorated motor disability in patients with Parkinson’s disease (PD). Here we report changes in neuromelanin (NM) imaging of dopaminergic neurons before and after rehabilitation combined with anodal tDCS over the FPA for 2 weeks in a PD patient. After the intervention, the patient showed clinically meaningful improvements while the NM-sensitive area in the SN increased by 18.8%. This case study is the first report of NM imaging of the SN in a PD patient who received tDCS. Abbreviations FPA: front polar area; PD: Parkinson’s disease; NM: neuromelanin; DCI: DOPA decarboxylase inhibitor; STEF: simple test for evaluating hand function; TUG: timed up and go test; TMT: trail-making test; SN: substantia nigra; NM-MRI: neuromelanin magnetic resonance imaging; MCID: the minimal clinically important difference; SNpc: substantia nigra pars compacta; VTA: ventral tegmental area; LC: locus coeruleus; PFC: prefrontal cortex; M1: primary motor cortex; MDS: Movement Disorder Society; MIBG: 123I-metaiodobenzylguanidine; SBR: specific binding ratio; SPECT: single-photon emission computed tomography; DAT: dopamine transporter; NIBS: noninvasive brain stimulation; tDCS: transcranial direct current stimulation; MAOB: monoamine oxidase B; DCI: decarboxylase inhibitor; repetitive transcranial magnetic stimulation: rTMS; diffusion tensor imaging: DTI; arterial spin labeling: ASL.

KW - NM-MRI

KW - Parkinson’s disease

KW - neuro-rehabilitation

KW - substantia nigra

KW - tDCS

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U2 - 10.1080/13554794.2021.1975768

DO - 10.1080/13554794.2021.1975768

M3 - 学術論文

C2 - 34503372

AN - SCOPUS:85114664812

SN - 1355-4794

VL - 27

SP - 407

EP - 414

JO - Neurocase

JF - Neurocase

IS - 5

ER -

A Parkinson’s disease patient displaying increased neuromelanin-sensitive areas in the substantia nigra after rehabilitation with tDCS: a case report

Abstract

Keywords

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