A new cytotoxic cardenolide from the roots of Calotropis gigantea

Mai T.T. Nguyen; Khang D.H. Nguyen; Phu H. Dang; Hai X. Nguyen; Suresh Awale; Nhan T. Nguyen

doi:10.1080/14786419.2020.1781114

A new cytotoxic cardenolide from the roots of Calotropis gigantea

Mai T.T. Nguyen, Khang D.H. Nguyen, Phu H. Dang, Hai X. Nguyen, Suresh Awale^*, Nhan T. Nguyen^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Bioactivity-guided isolation of the CHCl₃-soluble fraction of the roots of Calotropis gigantea was carried out to obtain a new cardenolide glycoside, caloside G. Its absolute structure was elucidated based on NMR and ECD spectroscopic data interpretation. Caloside G showed noteworthy cytotoxicity against the PANC-1 human pancreatic and HeLa human cervical carcinoma cell lines, with the submicromolar IC₅₀ values of 0.038 and 0.09 µM, respectively.

Original language	English
Pages (from-to)	5096-5101
Number of pages	6
Journal	Natural Product Research
Volume	35
Issue number	23
DOIs	https://doi.org/10.1080/14786419.2020.1781114
State	Published - 2021

Keywords

Calotropis gigantea
HeLa
PANC-1
cardenolide

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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10.1080/14786419.2020.1781114

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title = "A new cytotoxic cardenolide from the roots of Calotropis gigantea",

abstract = "Bioactivity-guided isolation of the CHCl3-soluble fraction of the roots of Calotropis gigantea was carried out to obtain a new cardenolide glycoside, caloside G. Its absolute structure was elucidated based on NMR and ECD spectroscopic data interpretation. Caloside G showed noteworthy cytotoxicity against the PANC-1 human pancreatic and HeLa human cervical carcinoma cell lines, with the submicromolar IC50 values of 0.038 and 0.09 µM, respectively.",

keywords = "Calotropis gigantea, HeLa, PANC-1, cardenolide",

author = "Nguyen, {Mai T.T.} and Nguyen, {Khang D.H.} and Dang, {Phu H.} and Nguyen, {Hai X.} and Suresh Awale and Nguyen, {Nhan T.}",

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year = "2021",

doi = "10.1080/14786419.2020.1781114",

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T1 - A new cytotoxic cardenolide from the roots of Calotropis gigantea

AU - Nguyen, Mai T.T.

AU - Nguyen, Khang D.H.

AU - Dang, Phu H.

AU - Nguyen, Hai X.

AU - Awale, Suresh

AU - Nguyen, Nhan T.

PY - 2021

Y1 - 2021

N2 - Bioactivity-guided isolation of the CHCl3-soluble fraction of the roots of Calotropis gigantea was carried out to obtain a new cardenolide glycoside, caloside G. Its absolute structure was elucidated based on NMR and ECD spectroscopic data interpretation. Caloside G showed noteworthy cytotoxicity against the PANC-1 human pancreatic and HeLa human cervical carcinoma cell lines, with the submicromolar IC50 values of 0.038 and 0.09 µM, respectively.

AB - Bioactivity-guided isolation of the CHCl3-soluble fraction of the roots of Calotropis gigantea was carried out to obtain a new cardenolide glycoside, caloside G. Its absolute structure was elucidated based on NMR and ECD spectroscopic data interpretation. Caloside G showed noteworthy cytotoxicity against the PANC-1 human pancreatic and HeLa human cervical carcinoma cell lines, with the submicromolar IC50 values of 0.038 and 0.09 µM, respectively.

KW - Calotropis gigantea

KW - HeLa

KW - PANC-1

KW - cardenolide

UR - http://www.scopus.com/inward/record.url?scp=85087370813&partnerID=8YFLogxK

U2 - 10.1080/14786419.2020.1781114

DO - 10.1080/14786419.2020.1781114

M3 - 学術論文

C2 - 32571094

AN - SCOPUS:85087370813

SN - 1478-6419

VL - 35

SP - 5096

EP - 5101

JO - Natural Product Research

JF - Natural Product Research

IS - 23

ER -

A new cytotoxic cardenolide from the roots of Calotropis gigantea

Abstract

Keywords

ASJC Scopus subject areas

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