A New alkenylphenol from the propolis of stingless bee trigona minor

Hai Xuan Nguyen; Truong Nhat Van Do; Mai Thanh Thi Nguyen; Phu Hoang Dang; Le Huu Tho; Suresh Awale; Nhan Trung Nguyen

doi:10.1177/1934578x1801300121

A New alkenylphenol from the propolis of stingless bee trigona minor

Hai Xuan Nguyen, Truong Nhat Van Do, Mai Thanh Thi Nguyen, Phu Hoang Dang, Le Huu Tho, Suresh Awale^*, Nhan Trung Nguyen

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new alkenylphenol, 2-hydroxyl-6-(14′Z-nonadecenyl)benzoic acid (1), was isolated from the ethanolic extract of Vietnamese stingless bee propolis Trigona minor (Meliponini, Apidae), together with two known compounds (2 and 3). Their chemical structures were determined by extensive NMR spectroscopic analysis. All compounds were tested for preferential cytotoxicity against the PANC-1 human pancreatic cell line under nutrition-deprived conditions (NDM). Compound 1 exhibited the strongest preferential cytotoxicity, with a PC₅₀ value of 2.4 μM.

Original language	English
Pages (from-to)	69-70
Number of pages	2
Journal	Natural Product Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1177/1934578x1801300121
State	Published - 2018/01

Keywords

NDM
PANC-1
Propolis
Stingless bee
Trigona minor

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

Access to Document

10.1177/1934578x1801300121

Cite this

@article{c3a83453925d46ecbeffdf0d7bdd7292,

title = "A New alkenylphenol from the propolis of stingless bee trigona minor",

abstract = "A new alkenylphenol, 2-hydroxyl-6-(14′Z-nonadecenyl)benzoic acid (1), was isolated from the ethanolic extract of Vietnamese stingless bee propolis Trigona minor (Meliponini, Apidae), together with two known compounds (2 and 3). Their chemical structures were determined by extensive NMR spectroscopic analysis. All compounds were tested for preferential cytotoxicity against the PANC-1 human pancreatic cell line under nutrition-deprived conditions (NDM). Compound 1 exhibited the strongest preferential cytotoxicity, with a PC50 value of 2.4 μM.",

keywords = "NDM, PANC-1, Propolis, Stingless bee, Trigona minor",

author = "Nguyen, {Hai Xuan} and {Van Do}, {Truong Nhat} and Nguyen, {Mai Thanh Thi} and Dang, {Phu Hoang} and Tho, {Le Huu} and Suresh Awale and Nguyen, {Nhan Trung}",

year = "2018",

month = jan,

doi = "10.1177/1934578x1801300121",

language = "英語",

volume = "13",

pages = "69--70",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "1",

}

TY - JOUR

T1 - A New alkenylphenol from the propolis of stingless bee trigona minor

AU - Nguyen, Hai Xuan

AU - Van Do, Truong Nhat

AU - Nguyen, Mai Thanh Thi

AU - Dang, Phu Hoang

AU - Tho, Le Huu

AU - Awale, Suresh

AU - Nguyen, Nhan Trung

PY - 2018/1

Y1 - 2018/1

N2 - A new alkenylphenol, 2-hydroxyl-6-(14′Z-nonadecenyl)benzoic acid (1), was isolated from the ethanolic extract of Vietnamese stingless bee propolis Trigona minor (Meliponini, Apidae), together with two known compounds (2 and 3). Their chemical structures were determined by extensive NMR spectroscopic analysis. All compounds were tested for preferential cytotoxicity against the PANC-1 human pancreatic cell line under nutrition-deprived conditions (NDM). Compound 1 exhibited the strongest preferential cytotoxicity, with a PC50 value of 2.4 μM.

AB - A new alkenylphenol, 2-hydroxyl-6-(14′Z-nonadecenyl)benzoic acid (1), was isolated from the ethanolic extract of Vietnamese stingless bee propolis Trigona minor (Meliponini, Apidae), together with two known compounds (2 and 3). Their chemical structures were determined by extensive NMR spectroscopic analysis. All compounds were tested for preferential cytotoxicity against the PANC-1 human pancreatic cell line under nutrition-deprived conditions (NDM). Compound 1 exhibited the strongest preferential cytotoxicity, with a PC50 value of 2.4 μM.

KW - NDM

KW - PANC-1

KW - Propolis

KW - Stingless bee

KW - Trigona minor

UR - http://www.scopus.com/inward/record.url?scp=85048474822&partnerID=8YFLogxK

U2 - 10.1177/1934578x1801300121

DO - 10.1177/1934578x1801300121

M3 - 学術論文

AN - SCOPUS:85048474822

SN - 1934-578X

VL - 13

SP - 69

EP - 70

JO - Natural Product Communications

JF - Natural Product Communications

IS - 1

ER -

A New alkenylphenol from the propolis of stingless bee trigona minor

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this