A metabolon at the heart of steroidal biosynthesis

Tsubasa Shoji; Satoru Sawai

doi:10.1016/j.tplants.2025.03.015

A metabolon at the heart of steroidal biosynthesis

Tsubasa Shoji^*, Satoru Sawai

^*Corresponding author for this work

Section of Pharmacognosy, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

Metabolons, dynamic enzyme assemblies critical for substrate channeling, underpin specialized metabolism. Recent studies by Boccia et al. and Jozwiak et al. in Solanum uncovered a cellulose synthase-like protein that orchestrates metabolon formation, functioning dually as a scaffold and glucuronosyltransferase in steroidal glycoalkaloid (SGA) and steroidal saponin (SS) biosynthesis, offering profound opportunities for metabolic engineering.

Original language	English
Journal	Trends in Plant Science
DOIs	https://doi.org/10.1016/j.tplants.2025.03.015
State	Accepted/In press - 2025

Keywords

cellulose synthase-like protein
metabolon
Solanum
steroidal glycoalkaloids
steroidal saponins

ASJC Scopus subject areas

Plant Science

Access to Document

10.1016/j.tplants.2025.03.015

Cite this

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title = "A metabolon at the heart of steroidal biosynthesis",

abstract = "Metabolons, dynamic enzyme assemblies critical for substrate channeling, underpin specialized metabolism. Recent studies by Boccia et al. and Jozwiak et al. in Solanum uncovered a cellulose synthase-like protein that orchestrates metabolon formation, functioning dually as a scaffold and glucuronosyltransferase in steroidal glycoalkaloid (SGA) and steroidal saponin (SS) biosynthesis, offering profound opportunities for metabolic engineering.",

keywords = "cellulose synthase-like protein, metabolon, Solanum, steroidal glycoalkaloids, steroidal saponins",

author = "Tsubasa Shoji and Satoru Sawai",

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year = "2025",

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journal = "Trends in Plant Science",

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AB - Metabolons, dynamic enzyme assemblies critical for substrate channeling, underpin specialized metabolism. Recent studies by Boccia et al. and Jozwiak et al. in Solanum uncovered a cellulose synthase-like protein that orchestrates metabolon formation, functioning dually as a scaffold and glucuronosyltransferase in steroidal glycoalkaloid (SGA) and steroidal saponin (SS) biosynthesis, offering profound opportunities for metabolic engineering.

KW - cellulose synthase-like protein

KW - metabolon

KW - Solanum

KW - steroidal glycoalkaloids

KW - steroidal saponins

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