TY - JOUR
T1 - A case of true malignant histiocytosis
T2 - Identification of histiocytic origin with use of immunohistochemical and immunocytogenetic methods
AU - Sato, T.
AU - Terui, T.
AU - Kogawa, K.
AU - Nagaoka, Y.
AU - Sato, Y.
AU - Iyama, S.
AU - Takada, K.
AU - Hagiwara, S.
AU - Takahashi, S.
AU - Oku, T.
AU - Matsunaga, T.
AU - Takahashi, M.
AU - Kato, J.
AU - Sakamaki, S.
AU - Torigoe, T.
AU - Sato, N.
AU - Hirayama, M.
AU - Niitsu, Y.
PY - 2002
Y1 - 2002
N2 - We report here an autopsy case of true malignant histiocytosis. The patient was a 67-year-old woman who exhibited fever, wasting, hepatosplenomegaly, and progressive pancytopenia. The bone marrow aspiration disclosed hemophagocytosing cells, which resembled histiocytes. The molecular analysis did not show the clonal gene rearrangement of T-cell receptor or immunoglobulin heavy chain. Although the patient had been started on methylprednisolone pulse therapy and chemotherapy with etoposide, she died from cerebral hemorrhage. The autopsy specimens of spleen and liver showed extensive infiltration of atypical cells, for which histiocytic origin was identified with an immunohistochemical method using monoclonal antibodies against CD11c, CD68, macrophage colony-stimulating factor (M-CSF), M-CSF receptor, lysozyme, antitrypsin and α1-antichymotrypsin. Recent investigations have disclosed that in most cases diagnosed as malignant histiocytosis, hemophagocytosis was reactive and not evoked by histiocytic malignancy. True malignant histiocytosis, for which histiocytic origin is confirmed, is extremely rare.
AB - We report here an autopsy case of true malignant histiocytosis. The patient was a 67-year-old woman who exhibited fever, wasting, hepatosplenomegaly, and progressive pancytopenia. The bone marrow aspiration disclosed hemophagocytosing cells, which resembled histiocytes. The molecular analysis did not show the clonal gene rearrangement of T-cell receptor or immunoglobulin heavy chain. Although the patient had been started on methylprednisolone pulse therapy and chemotherapy with etoposide, she died from cerebral hemorrhage. The autopsy specimens of spleen and liver showed extensive infiltration of atypical cells, for which histiocytic origin was identified with an immunohistochemical method using monoclonal antibodies against CD11c, CD68, macrophage colony-stimulating factor (M-CSF), M-CSF receptor, lysozyme, antitrypsin and α1-antichymotrypsin. Recent investigations have disclosed that in most cases diagnosed as malignant histiocytosis, hemophagocytosis was reactive and not evoked by histiocytic malignancy. True malignant histiocytosis, for which histiocytic origin is confirmed, is extremely rare.
KW - Gene rearrangement
KW - Histiocytic origin
KW - Immunohistochemical staining
KW - True malignant histiocytosis
UR - http://www.scopus.com/inward/record.url?scp=0036942858&partnerID=8YFLogxK
U2 - 10.1007/s00277-002-0446-7
DO - 10.1007/s00277-002-0446-7
M3 - 学術論文
C2 - 12029539
AN - SCOPUS:0036942858
SN - 0939-5555
VL - 81
SP - 285
EP - 288
JO - Annals of Hematology
JF - Annals of Hematology
IS - 5
ER -