A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation

Makiko Nakamura; Teruhiko Imamura; Kohji Takagi; Masakazu Hori; Shinichi Tanaka; Joji Imura; Koichiro Kinugawa

doi:10.3390/jcdd9020038

A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation

Makiko Nakamura, Teruhiko Imamura^*, Kohji Takagi, Masakazu Hori, Shinichi Tanaka, Joji Imura, Koichiro Kinugawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Post-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy are effective. However, patients with T/NK-cell PTLD post-cardiac transplantation are rarely reported. We had a patient with a fever that lasted for three weeks, with lung infiltrations and hepatosplenomegaly, who had EBV-associated hemophagocytosis 7 years after heart transplantation and was eventually diagnosed with T/NK-cell PTLD by autopsy. Although rare diseases, regular monitoring of EBV-DNA levels might be crucial for early diagnosis and treatment of PTLD.

Original language	English
Article number	38
Journal	Journal of Cardiovascular Development and Disease
Volume	9
Issue number	2
DOIs	https://doi.org/10.3390/jcdd9020038
State	Published - 2022/02

Keywords

Cardiomyopathy
Epstein–Barr virus
Hemophagocytosis
Immunosupressant

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pharmacology (medical)

Access to Document

10.3390/jcdd9020038

Cite this

@article{273bd3a3530b4e64b2379bfa0b0521dd,

title = "A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation",

abstract = "Post-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy are effective. However, patients with T/NK-cell PTLD post-cardiac transplantation are rarely reported. We had a patient with a fever that lasted for three weeks, with lung infiltrations and hepatosplenomegaly, who had EBV-associated hemophagocytosis 7 years after heart transplantation and was eventually diagnosed with T/NK-cell PTLD by autopsy. Although rare diseases, regular monitoring of EBV-DNA levels might be crucial for early diagnosis and treatment of PTLD.",

keywords = "Cardiomyopathy, Epstein–Barr virus, Hemophagocytosis, Immunosupressant",

author = "Makiko Nakamura and Teruhiko Imamura and Kohji Takagi and Masakazu Hori and Shinichi Tanaka and Joji Imura and Koichiro Kinugawa",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

doi = "10.3390/jcdd9020038",

language = "英語",

volume = "9",

journal = "Journal of Cardiovascular Development and Disease",

issn = "2308-3425",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "2",

}

TY - JOUR

T1 - A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation

AU - Nakamura, Makiko

AU - Imamura, Teruhiko

AU - Takagi, Kohji

AU - Hori, Masakazu

AU - Tanaka, Shinichi

AU - Imura, Joji

AU - Kinugawa, Koichiro

PY - 2022/2

Y1 - 2022/2

N2 - Post-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy are effective. However, patients with T/NK-cell PTLD post-cardiac transplantation are rarely reported. We had a patient with a fever that lasted for three weeks, with lung infiltrations and hepatosplenomegaly, who had EBV-associated hemophagocytosis 7 years after heart transplantation and was eventually diagnosed with T/NK-cell PTLD by autopsy. Although rare diseases, regular monitoring of EBV-DNA levels might be crucial for early diagnosis and treatment of PTLD.

AB - Post-transplant lymphoproliferative diseases (PTLD) are potentially fatal complications after cardiac transplantation. Most cases are Epstein–Barr virus (EBV)-related B-cell tumors, and reduction of immunosuppression treatment as well as the use of rituximab in combination with other chemotherapy are effective. However, patients with T/NK-cell PTLD post-cardiac transplantation are rarely reported. We had a patient with a fever that lasted for three weeks, with lung infiltrations and hepatosplenomegaly, who had EBV-associated hemophagocytosis 7 years after heart transplantation and was eventually diagnosed with T/NK-cell PTLD by autopsy. Although rare diseases, regular monitoring of EBV-DNA levels might be crucial for early diagnosis and treatment of PTLD.

KW - Cardiomyopathy

KW - Epstein–Barr virus

KW - Hemophagocytosis

KW - Immunosupressant

UR - http://www.scopus.com/inward/record.url?scp=85123988776&partnerID=8YFLogxK

U2 - 10.3390/jcdd9020038

DO - 10.3390/jcdd9020038

M3 - 学術論文

C2 - 35200692

AN - SCOPUS:85123988776

SN - 2308-3425

VL - 9

JO - Journal of Cardiovascular Development and Disease

JF - Journal of Cardiovascular Development and Disease

IS - 2

M1 - 38

ER -

A Case of T/NK-Cell Post-Transplantation Lymphoproliferative Disease 7 Years after Heart Transplantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this