A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment

Koichi Izumikawa; Yong Zhao; Kohei Motoshima; Takahiro Takazono; Tomomi Saijo; Sintaro Kurihara; Shigeki Nakamura; Taiga Miyazaki; Masafumi Seki; Hiroshi Kakeya; Yoshihiro Yamamoto; Katsunori Yanagihara; Yoshitsugu Miyazaki; Tomayoshi Hayashi; Shigeru Kohno

doi:10.1080/13693780802074494

A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment

Koichi Izumikawa^*, Yong Zhao, Kohei Motoshima, Takahiro Takazono, Tomomi Saijo, Sintaro Kurihara, Shigeki Nakamura, Taiga Miyazaki, Masafumi Seki, Hiroshi Kakeya, Yoshihiro Yamamoto, Katsunori Yanagihara, Yoshitsugu Miyazaki, Tomayoshi Hayashi, Shigeru Kohno

^*Corresponding author for this work

Clinical Infectious Diseases

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Cryptococcal pleuritis is rare in individuals with no underlying disease. We report a case of pulmonary cryptococcosis followed by pleuritis in a patient on fluconazole treatment. Biopsy of the pleura revealed a granuloma and a cryptococcal body, while PCR and sequence analysis of extracted DNA from the pleura proved the presence of Cryptococcus species, most likely C. neoformans. Voriconazole with flucytosine and drainage of the pleural effusion were effective in treating the patient.

Original language	English
Pages (from-to)	595-599
Number of pages	5
Journal	Medical Mycology
Volume	46
Issue number	6
DOIs	https://doi.org/10.1080/13693780802074494
State	Published - 2008

Keywords

Cryptococcus
Fluconazole
Pleuritis

ASJC Scopus subject areas

Infectious Diseases

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Izumikawa, K., Zhao, Y., Motoshima, K., Takazono, T., Saijo, T., Kurihara, S., Nakamura, S., Miyazaki, T., Seki, M., Kakeya, H., Yamamoto, Y., Yanagihara, K., Miyazaki, Y., Hayashi, T., & Kohno, S. (2008). A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment. Medical Mycology, 46(6), 595-599. https://doi.org/10.1080/13693780802074494

@article{b8fe770198504b7cb5e5eb8aece8e2c8,

title = "A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment",

abstract = "Cryptococcal pleuritis is rare in individuals with no underlying disease. We report a case of pulmonary cryptococcosis followed by pleuritis in a patient on fluconazole treatment. Biopsy of the pleura revealed a granuloma and a cryptococcal body, while PCR and sequence analysis of extracted DNA from the pleura proved the presence of Cryptococcus species, most likely C. neoformans. Voriconazole with flucytosine and drainage of the pleural effusion were effective in treating the patient.",

keywords = "Cryptococcus, Fluconazole, Pleuritis",

author = "Koichi Izumikawa and Yong Zhao and Kohei Motoshima and Takahiro Takazono and Tomomi Saijo and Sintaro Kurihara and Shigeki Nakamura and Taiga Miyazaki and Masafumi Seki and Hiroshi Kakeya and Yoshihiro Yamamoto and Katsunori Yanagihara and Yoshitsugu Miyazaki and Tomayoshi Hayashi and Shigeru Kohno",

year = "2008",

doi = "10.1080/13693780802074494",

language = "英語",

volume = "46",

pages = "595--599",

journal = "Medical Mycology",

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publisher = "Oxford University Press",

number = "6",

}

Izumikawa, K, Zhao, Y, Motoshima, K, Takazono, T, Saijo, T, Kurihara, S, Nakamura, S, Miyazaki, T, Seki, M, Kakeya, H, Yamamoto, Y, Yanagihara, K, Miyazaki, Y, Hayashi, T & Kohno, S 2008, 'A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment', Medical Mycology, vol. 46, no. 6, pp. 595-599. https://doi.org/10.1080/13693780802074494

TY - JOUR

T1 - A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment

AU - Izumikawa, Koichi

AU - Zhao, Yong

AU - Motoshima, Kohei

AU - Takazono, Takahiro

AU - Saijo, Tomomi

AU - Kurihara, Sintaro

AU - Nakamura, Shigeki

AU - Miyazaki, Taiga

AU - Seki, Masafumi

AU - Kakeya, Hiroshi

AU - Yamamoto, Yoshihiro

AU - Yanagihara, Katsunori

AU - Miyazaki, Yoshitsugu

AU - Hayashi, Tomayoshi

AU - Kohno, Shigeru

PY - 2008

Y1 - 2008

N2 - Cryptococcal pleuritis is rare in individuals with no underlying disease. We report a case of pulmonary cryptococcosis followed by pleuritis in a patient on fluconazole treatment. Biopsy of the pleura revealed a granuloma and a cryptococcal body, while PCR and sequence analysis of extracted DNA from the pleura proved the presence of Cryptococcus species, most likely C. neoformans. Voriconazole with flucytosine and drainage of the pleural effusion were effective in treating the patient.

AB - Cryptococcal pleuritis is rare in individuals with no underlying disease. We report a case of pulmonary cryptococcosis followed by pleuritis in a patient on fluconazole treatment. Biopsy of the pleura revealed a granuloma and a cryptococcal body, while PCR and sequence analysis of extracted DNA from the pleura proved the presence of Cryptococcus species, most likely C. neoformans. Voriconazole with flucytosine and drainage of the pleural effusion were effective in treating the patient.

KW - Cryptococcus

KW - Fluconazole

KW - Pleuritis

UR - http://www.scopus.com/inward/record.url?scp=51649125998&partnerID=8YFLogxK

U2 - 10.1080/13693780802074494

DO - 10.1080/13693780802074494

M3 - 学術論文

C2 - 19180728

AN - SCOPUS:51649125998

SN - 1369-3786

VL - 46

SP - 595

EP - 599

JO - Medical Mycology

JF - Medical Mycology

IS - 6

ER -

A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment

Abstract

Keywords

ASJC Scopus subject areas

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