A case of Parkinson's disease following autoimmune autonomic ganglionopathy

Akihiko Mitsutake; Hideyuki Matsumoto; Keiko Hatano; Osamu Higuchi; Shunya Nakane; Hideji Hashida

doi:10.1111/ncn3.12288

A case of Parkinson's disease following autoimmune autonomic ganglionopathy

Akihiko Mitsutake^*, Hideyuki Matsumoto, Keiko Hatano, Osamu Higuchi, Shunya Nakane, Hideji Hashida

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

The patient is an 80-year-old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti-gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson's disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti-gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.

Original language	English
Pages (from-to)	212-214
Number of pages	3
Journal	Neurology and Clinical Neuroscience
Volume	7
Issue number	4
DOIs	https://doi.org/10.1111/ncn3.12288
State	Published - 2019/07

Keywords

123I-MIBG myocardial scintigraphy
anti-ganglionic acetylcholine receptor antibody
autoimmune autonomic ganglionopathy
DAT SPECT
Parkinson's disease

ASJC Scopus subject areas

Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/ncn3.12288

Cite this

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title = "A case of Parkinson's disease following autoimmune autonomic ganglionopathy",

abstract = "The patient is an 80-year-old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti-gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson's disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti-gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.",

keywords = "123I-MIBG myocardial scintigraphy, anti-ganglionic acetylcholine receptor antibody, autoimmune autonomic ganglionopathy, DAT SPECT, Parkinson's disease",

author = "Akihiko Mitsutake and Hideyuki Matsumoto and Keiko Hatano and Osamu Higuchi and Shunya Nakane and Hideji Hashida",

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year = "2019",

month = jul,

doi = "10.1111/ncn3.12288",

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T1 - A case of Parkinson's disease following autoimmune autonomic ganglionopathy

AU - Mitsutake, Akihiko

AU - Matsumoto, Hideyuki

AU - Hatano, Keiko

AU - Higuchi, Osamu

AU - Nakane, Shunya

AU - Hashida, Hideji

PY - 2019/7

Y1 - 2019/7

N2 - The patient is an 80-year-old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti-gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson's disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti-gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.

AB - The patient is an 80-year-old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti-gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson's disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti-gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.

KW - 123I-MIBG myocardial scintigraphy

KW - anti-ganglionic acetylcholine receptor antibody

KW - autoimmune autonomic ganglionopathy

KW - DAT SPECT

KW - Parkinson's disease

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SN - 2049-4173

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A case of Parkinson's disease following autoimmune autonomic ganglionopathy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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