A case of Parkinson's disease following autoimmune autonomic ganglionopathy

Akihiko Mitsutake*, Hideyuki Matsumoto, Keiko Hatano, Osamu Higuchi, Shunya Nakane, Hideji Hashida

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The patient is an 80-year-old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti-gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson's disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti-gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.

Original languageEnglish
Pages (from-to)212-214
Number of pages3
JournalNeurology and Clinical Neuroscience
Volume7
Issue number4
DOIs
StatePublished - 2019/07

Keywords

  • 123I-MIBG myocardial scintigraphy
  • anti-ganglionic acetylcholine receptor antibody
  • autoimmune autonomic ganglionopathy
  • DAT SPECT
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'A case of Parkinson's disease following autoimmune autonomic ganglionopathy'. Together they form a unique fingerprint.

Cite this