Abstract
The patient is an 80-year-old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autonomic ganglionopathy (AAG) based on acute onset autonomic dysfunction, positive anti-gAChR antibodies, and efficacy of prednisolone. After the event of AAG, he gradually developed Parkinson's disease (PD). Parkinsonism is described as a complication of AAG in the previous literature. Anti-gAChR antibodies might inhibit dopamine neurotransmission and be associated with the development of PD.
Original language | English |
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Pages (from-to) | 212-214 |
Number of pages | 3 |
Journal | Neurology and Clinical Neuroscience |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - 2019/07 |
Keywords
- 123I-MIBG myocardial scintigraphy
- anti-ganglionic acetylcholine receptor antibody
- autoimmune autonomic ganglionopathy
- DAT SPECT
- Parkinson's disease
ASJC Scopus subject areas
- Neurology
- Clinical Neurology