TY - JOUR
T1 - A case of 'lymphomatosis cerebri' diagnosed in an early phase and treated by whole brain radiation
T2 - Case report and literature review
AU - Kanai, Ryuichi
AU - Shibuya, Makoto
AU - Hata, Takashi
AU - Hori, Makoto
AU - Hirabayashi, Kenichi
AU - Terada, Tadashi
AU - Fujii, Koji
N1 - Funding Information:
The work was financially supported by the Foundation of NUIST-UoR International Research Institute , the Startup Foundation for Introducing Talent of NUIST ( 2018r056 ).
PY - 2008/1
Y1 - 2008/1
N2 - 'Lymphomatosis cerebri' (LC) is a term indicating a diffusely infiltrating form of primary central nervous system lymphoma (PCNSL) without evidence of a mass lesion. Not infrequently, diagnostic confusion is caused by its presentation on cranial magnetic resonance images (MRI), which is characterized by diffuse leukoencephalopathy without contrast enhancement. In this report, we describe a 53-year-old, immunocompetent man who had an insidiously progressive dementia and right weakness. On serial MRI in 4 months duration, diffuse white matter lesions without contrast enhancement gradually progressed, which was clinically consistent with his worsening condition. Biopsy specimen demonstrated nondestructive, diffusely infiltrating, large B-cell lymphoma, diagnosing LC. After the biopsy, corticosteroids were initiated, which dramatically alleviated his symptoms. Afterwards, he was treated by whole brain irradiation (total 36Gy) and discharged without noticeable deficits. Diagnosis of LC requires additional examinations generally not performed in the other white matter disorders. In suspected cases, biopsy should be performed to avoid deferring adequate cytostatic treatment.
AB - 'Lymphomatosis cerebri' (LC) is a term indicating a diffusely infiltrating form of primary central nervous system lymphoma (PCNSL) without evidence of a mass lesion. Not infrequently, diagnostic confusion is caused by its presentation on cranial magnetic resonance images (MRI), which is characterized by diffuse leukoencephalopathy without contrast enhancement. In this report, we describe a 53-year-old, immunocompetent man who had an insidiously progressive dementia and right weakness. On serial MRI in 4 months duration, diffuse white matter lesions without contrast enhancement gradually progressed, which was clinically consistent with his worsening condition. Biopsy specimen demonstrated nondestructive, diffusely infiltrating, large B-cell lymphoma, diagnosing LC. After the biopsy, corticosteroids were initiated, which dramatically alleviated his symptoms. Afterwards, he was treated by whole brain irradiation (total 36Gy) and discharged without noticeable deficits. Diagnosis of LC requires additional examinations generally not performed in the other white matter disorders. In suspected cases, biopsy should be performed to avoid deferring adequate cytostatic treatment.
KW - Leukoencephalopathy
KW - Lymphomatosis cerebri
KW - Magnetic resonance imaging
KW - PrimaryCNS lymphoma
KW - White matter dementia
UR - http://www.scopus.com/inward/record.url?scp=37248999844&partnerID=8YFLogxK
U2 - 10.1007/s11060-007-9437-9
DO - 10.1007/s11060-007-9437-9
M3 - 総説
C2 - 17611716
AN - SCOPUS:37248999844
SN - 0167-594X
VL - 86
SP - 83
EP - 88
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 1
ER -
