A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis

Tomoki Fukuyama; Hiromu Kawahara; Masayoshi Yamada; Nobuhiko Hayashi; Hirokazu Yano; Masayuki Fukura; Kazuaki Ozaki; Mutsumi Tsuchishima; Shujiro Takase; Tomiyasu Arisawa; Kazuhiko Omote; Takayuki Nojima

A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis

Tomoki Fukuyama^*, Hiromu Kawahara, Masayoshi Yamada, Nobuhiko Hayashi, Hirokazu Yano, Masayuki Fukura, Kazuaki Ozaki, Mutsumi Tsuchishima, Shujiro Takase, Tomiyasu Arisawa, Kazuhiko Omote, Takayuki Nojima

^*Corresponding author for this work

Internal Medicine （3）

Research output: Contribution to journal › Article › peer-review

Abstract

A 77-year-old man was admitted to our hospital with abdominal pain and ascites. He had an occupational history of working with asbestos. Abdominal CT showed multiple nodular lesions with enhancement by contrast medium in the cavity. Platelet counts, CRP and serum IL-6 level were increased. Biopsied materials obtained by laparoscopy showed oval cells with rich cytoplasm growing in an epithelial pattern. To clarify the characteristics of the cells, immunohistochemistry was performed. Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma. Because IL-6, IL-6 receptor and VEGF were expressed markedly, the patient received chemotherapy for IL-6 suppression. During the treatment, thrombocytosis imploved satisfactorily.

Original language	English
Pages (from-to)	546-553
Number of pages	8
Journal	Journal of Japanese Society of Gastroenterology
Volume	106
Issue number	4
State	Published - 2009

ASJC Scopus subject areas

Gastroenterology

Cite this

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title = "A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis",

abstract = "A 77-year-old man was admitted to our hospital with abdominal pain and ascites. He had an occupational history of working with asbestos. Abdominal CT showed multiple nodular lesions with enhancement by contrast medium in the cavity. Platelet counts, CRP and serum IL-6 level were increased. Biopsied materials obtained by laparoscopy showed oval cells with rich cytoplasm growing in an epithelial pattern. To clarify the characteristics of the cells, immunohistochemistry was performed. Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma. Because IL-6, IL-6 receptor and VEGF were expressed markedly, the patient received chemotherapy for IL-6 suppression. During the treatment, thrombocytosis imploved satisfactorily.",

author = "Tomoki Fukuyama and Hiromu Kawahara and Masayoshi Yamada and Nobuhiko Hayashi and Hirokazu Yano and Masayuki Fukura and Kazuaki Ozaki and Mutsumi Tsuchishima and Shujiro Takase and Tomiyasu Arisawa and Kazuhiko Omote and Takayuki Nojima",

year = "2009",

language = "英語",

volume = "106",

pages = "546--553",

journal = "Journal of Japanese Society of Gastroenterology",

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publisher = "Japanese Society of Gastroenterology",

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TY - JOUR

T1 - A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis

AU - Fukuyama, Tomoki

AU - Kawahara, Hiromu

AU - Yamada, Masayoshi

AU - Hayashi, Nobuhiko

AU - Yano, Hirokazu

AU - Fukura, Masayuki

AU - Ozaki, Kazuaki

AU - Tsuchishima, Mutsumi

AU - Takase, Shujiro

AU - Arisawa, Tomiyasu

AU - Omote, Kazuhiko

AU - Nojima, Takayuki

PY - 2009

Y1 - 2009

N2 - A 77-year-old man was admitted to our hospital with abdominal pain and ascites. He had an occupational history of working with asbestos. Abdominal CT showed multiple nodular lesions with enhancement by contrast medium in the cavity. Platelet counts, CRP and serum IL-6 level were increased. Biopsied materials obtained by laparoscopy showed oval cells with rich cytoplasm growing in an epithelial pattern. To clarify the characteristics of the cells, immunohistochemistry was performed. Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma. Because IL-6, IL-6 receptor and VEGF were expressed markedly, the patient received chemotherapy for IL-6 suppression. During the treatment, thrombocytosis imploved satisfactorily.

AB - A 77-year-old man was admitted to our hospital with abdominal pain and ascites. He had an occupational history of working with asbestos. Abdominal CT showed multiple nodular lesions with enhancement by contrast medium in the cavity. Platelet counts, CRP and serum IL-6 level were increased. Biopsied materials obtained by laparoscopy showed oval cells with rich cytoplasm growing in an epithelial pattern. To clarify the characteristics of the cells, immunohistochemistry was performed. Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma. Because IL-6, IL-6 receptor and VEGF were expressed markedly, the patient received chemotherapy for IL-6 suppression. During the treatment, thrombocytosis imploved satisfactorily.

UR - http://www.scopus.com/inward/record.url?scp=71949100325&partnerID=8YFLogxK

M3 - 学術論文

C2 - 19346724

AN - SCOPUS:71949100325

SN - 0446-6586

VL - 106

SP - 546

EP - 553

JO - Journal of Japanese Society of Gastroenterology

JF - Journal of Japanese Society of Gastroenterology

IS - 4

ER -

A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis

Abstract

ASJC Scopus subject areas

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