A case of diabetic ketoacidosis induced by chlormadinone acetate

N. Nakamura; M. Narukawa; T. Asahi; K. Yamazaki; A. Sato; R. Temaru; M. Urakaze; T. Sasaoka; S. Ogaku; M. Kobayashi

A case of diabetic ketoacidosis induced by chlormadinone acetate

N. Nakamura^*, M. Narukawa, T. Asahi, K. Yamazaki, A. Sato, R. Temaru, M. Urakaze, T. Sasaoka, S. Ogaku, M. Kobayashi

^*Corresponding author for this work

Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An 84-year-old male was hospitalized on Oct. 13, 1996. On admission lab values were as follows: plasma glucose concentration (928 mg/dl), arterial blood gas analysis (pH 7.201, PaCO₂ 16.2 mmHg, HCO₃ 6.3 mmol/l). All signs indicated severe hyperglycemia with metabolic acidosis. Under a diagnosis of diabetic ketoacidosis (DKA), he was immediately transfused with fluid, insulin and antibiotics. With these treatments, his general condition gradually improved for about 3 days. His past history revealed that chlormadinone acetate (CMA) had been administered for the treatment of prostatic cancer. Our experience with this patient suggested that CMA might have induced DKA, and furthermore that examination of glucose metabolism was prudent in patients under going CMA treatment.

Original language	English
Pages (from-to)	923-928
Number of pages	6
Journal	Journal of the Japan Diabetes Society
Volume	41
Issue number	10
State	Published - 1998

Keywords

Chlormadinone acetate
Diabetic ketoacidosis
Hyperglycemia
Prostatic cancer

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "A case of diabetic ketoacidosis induced by chlormadinone acetate",

abstract = "An 84-year-old male was hospitalized on Oct. 13, 1996. On admission lab values were as follows: plasma glucose concentration (928 mg/dl), arterial blood gas analysis (pH 7.201, PaCO2 16.2 mmHg, HCO3 6.3 mmol/l). All signs indicated severe hyperglycemia with metabolic acidosis. Under a diagnosis of diabetic ketoacidosis (DKA), he was immediately transfused with fluid, insulin and antibiotics. With these treatments, his general condition gradually improved for about 3 days. His past history revealed that chlormadinone acetate (CMA) had been administered for the treatment of prostatic cancer. Our experience with this patient suggested that CMA might have induced DKA, and furthermore that examination of glucose metabolism was prudent in patients under going CMA treatment.",

keywords = "Chlormadinone acetate, Diabetic ketoacidosis, Hyperglycemia, Prostatic cancer",

author = "N. Nakamura and M. Narukawa and T. Asahi and K. Yamazaki and A. Sato and R. Temaru and M. Urakaze and T. Sasaoka and S. Ogaku and M. Kobayashi",

year = "1998",

language = "英語",

volume = "41",

pages = "923--928",

journal = "Journal of the Japan Diabetes Society",

issn = "0021-437X",

publisher = "Japan Diabetes Society",

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TY - JOUR

T1 - A case of diabetic ketoacidosis induced by chlormadinone acetate

AU - Nakamura, N.

AU - Narukawa, M.

AU - Asahi, T.

AU - Yamazaki, K.

AU - Sato, A.

AU - Temaru, R.

AU - Urakaze, M.

AU - Sasaoka, T.

AU - Ogaku, S.

AU - Kobayashi, M.

PY - 1998

Y1 - 1998

N2 - An 84-year-old male was hospitalized on Oct. 13, 1996. On admission lab values were as follows: plasma glucose concentration (928 mg/dl), arterial blood gas analysis (pH 7.201, PaCO2 16.2 mmHg, HCO3 6.3 mmol/l). All signs indicated severe hyperglycemia with metabolic acidosis. Under a diagnosis of diabetic ketoacidosis (DKA), he was immediately transfused with fluid, insulin and antibiotics. With these treatments, his general condition gradually improved for about 3 days. His past history revealed that chlormadinone acetate (CMA) had been administered for the treatment of prostatic cancer. Our experience with this patient suggested that CMA might have induced DKA, and furthermore that examination of glucose metabolism was prudent in patients under going CMA treatment.

AB - An 84-year-old male was hospitalized on Oct. 13, 1996. On admission lab values were as follows: plasma glucose concentration (928 mg/dl), arterial blood gas analysis (pH 7.201, PaCO2 16.2 mmHg, HCO3 6.3 mmol/l). All signs indicated severe hyperglycemia with metabolic acidosis. Under a diagnosis of diabetic ketoacidosis (DKA), he was immediately transfused with fluid, insulin and antibiotics. With these treatments, his general condition gradually improved for about 3 days. His past history revealed that chlormadinone acetate (CMA) had been administered for the treatment of prostatic cancer. Our experience with this patient suggested that CMA might have induced DKA, and furthermore that examination of glucose metabolism was prudent in patients under going CMA treatment.

KW - Chlormadinone acetate

KW - Diabetic ketoacidosis

KW - Hyperglycemia

KW - Prostatic cancer

UR - http://www.scopus.com/inward/record.url?scp=0031730787&partnerID=8YFLogxK

M3 - 学術論文

AN - SCOPUS:0031730787

SN - 0021-437X

VL - 41

SP - 923

EP - 928

JO - Journal of the Japan Diabetes Society

JF - Journal of the Japan Diabetes Society

IS - 10

ER -

A case of diabetic ketoacidosis induced by chlormadinone acetate

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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