TY - JOUR
T1 - A case of anti-neurofascin 155 antibody-positive combined central and peripheral demyelination successfully treated with plasma exchange
AU - Shimizu, Mikito
AU - Koda, Tohru
AU - Nakatsuji, Yuji
AU - Ogata, Hidenori
AU - Kira, Jun ichi
AU - Mochizuki, Hideki
PY - 2017
Y1 - 2017
N2 - A 21-year-old man was admitted to our hospital in June 2015. He felt paresthesia of toes in April 2015, which had been spreading upward, and he became difficult to walk in June. Nerve conduction study showed peripheral demyelinating neuropathy that met the diagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), and the cerebrospinal fluid (CSF) examination revealed the remarkably increased protein level. In addition, magnetic resonance imaging of his brain showed a few plaques in white matter, so he was finally diagnosed with combined central and peripheral demyelination (CCPD). Moreover, anti-neurofascin155 (NF155) antibodies assayed in his serum and CSF turned out to be positive. Although he was treated with intravenous immunoglobulin and intravenous methylprednisolone, his symptoms were not ameliorated. However, plasma exchange therapy was apparently effective, and the titer of anti-NF155 antibody was reduced. Recently, the number of case reports of CIDP with CNS lesions has gradually been increasing, while the information about the diagnosis and the treatment responses are not enough. Thus, we reported our case with CCPD who was successfully treated with plasma exchange.
AB - A 21-year-old man was admitted to our hospital in June 2015. He felt paresthesia of toes in April 2015, which had been spreading upward, and he became difficult to walk in June. Nerve conduction study showed peripheral demyelinating neuropathy that met the diagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), and the cerebrospinal fluid (CSF) examination revealed the remarkably increased protein level. In addition, magnetic resonance imaging of his brain showed a few plaques in white matter, so he was finally diagnosed with combined central and peripheral demyelination (CCPD). Moreover, anti-neurofascin155 (NF155) antibodies assayed in his serum and CSF turned out to be positive. Although he was treated with intravenous immunoglobulin and intravenous methylprednisolone, his symptoms were not ameliorated. However, plasma exchange therapy was apparently effective, and the titer of anti-NF155 antibody was reduced. Recently, the number of case reports of CIDP with CNS lesions has gradually been increasing, while the information about the diagnosis and the treatment responses are not enough. Thus, we reported our case with CCPD who was successfully treated with plasma exchange.
KW - Anti-neurofascin155 antibody
KW - Chronic inflammatory demyelinating polyneuropathy
KW - Combined central and peripheral demyelination
KW - Simple plasma exchange
UR - http://www.scopus.com/inward/record.url?scp=85011965437&partnerID=8YFLogxK
U2 - 10.5692/clinicalneurol.cn-000964
DO - 10.5692/clinicalneurol.cn-000964
M3 - 学術論文
C2 - 28025411
AN - SCOPUS:85011965437
SN - 0009-918X
VL - 57
SP - 41
EP - 44
JO - Clinical Neurology
JF - Clinical Neurology
IS - 1
ER -