TY - JOUR
T1 - A carcinoembryonic antigen family cDNA from mouse placenta encoding a protein with a rare domain composition
AU - Kataoka, K.
AU - Takata, Y.
AU - Nakajima, A.
AU - Saito, S.
AU - Huh, N.
N1 - Funding Information:
The authors sincerely thank Dr Mikiro Takaishi and Dr Masato Aoki for their technical help and critical discussion. This work was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan.
PY - 2000
Y1 - 2000
N2 - The carcinoembryonic antigen (CEA) family comprises many members with pleiotropic functions. Among normal tissues, placenta is characterized by the abundant production of many different kinds of CEA-related proteins, which are apparently important for the maintenance of pregnancy. Using RNA differential display applied to mouse placentae at different gestational days, we have isolated a novel CEA-related cDNA designated as Ceacam11. Ceacam11 cDNA encodes 303 amino acids with a possible signal peptide and two immunoglobulin variable region-like domains. This domain composition is observed only in mouse Cea10/Ceacam 10 among the many CEA family members thus far reported. The transcript of Ceacam11 was first detected was first detected in the placenta at 12.5 days post-coitus (dpc) and the level increased progressively towards 17.5 dpc. The expression of Ceacam11 appears to be reciprocal to that of Ceacam10, since the Ceacam10 transcripts were detected at 8.5 and 10.5 dpc, but not at 12.5 to 17.5 dpc. In situ hybridization showed that the expression of Ceacam11 was localized to the spongiotrophoblast of the placenta. Except for in the placenta, Ceacam11 transcripts were not detected in any adult tissues examined, including brain, lung, glandular stomach, small intestine, colon, liver, kidney and testis. (C) 2000 Harcourt Publishers Ltd.
AB - The carcinoembryonic antigen (CEA) family comprises many members with pleiotropic functions. Among normal tissues, placenta is characterized by the abundant production of many different kinds of CEA-related proteins, which are apparently important for the maintenance of pregnancy. Using RNA differential display applied to mouse placentae at different gestational days, we have isolated a novel CEA-related cDNA designated as Ceacam11. Ceacam11 cDNA encodes 303 amino acids with a possible signal peptide and two immunoglobulin variable region-like domains. This domain composition is observed only in mouse Cea10/Ceacam 10 among the many CEA family members thus far reported. The transcript of Ceacam11 was first detected was first detected in the placenta at 12.5 days post-coitus (dpc) and the level increased progressively towards 17.5 dpc. The expression of Ceacam11 appears to be reciprocal to that of Ceacam10, since the Ceacam10 transcripts were detected at 8.5 and 10.5 dpc, but not at 12.5 to 17.5 dpc. In situ hybridization showed that the expression of Ceacam11 was localized to the spongiotrophoblast of the placenta. Except for in the placenta, Ceacam11 transcripts were not detected in any adult tissues examined, including brain, lung, glandular stomach, small intestine, colon, liver, kidney and testis. (C) 2000 Harcourt Publishers Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0033824243&partnerID=8YFLogxK
U2 - 10.1053/plac.2000.0546
DO - 10.1053/plac.2000.0546
M3 - 学術論文
C2 - 10985962
AN - SCOPUS:0033824243
SN - 0143-4004
VL - 21
SP - 610
EP - 614
JO - Placenta
JF - Placenta
IS - 7
ER -