5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon

Makoto Kadowaki; Xia Obiao Wang; Hidehiko Shimatani; Satoshi Yoneda; Miyako Takaki

doi:10.1016/S1566-0702(02)00063-2

5-HT₄ receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon

Makoto Kadowaki^*, Xia Obiao Wang, Hidehiko Shimatani, Satoshi Yoneda, Miyako Takaki

^*Corresponding author for this work

Research Center for Pre-Disease Science

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The present study was designed to investigate the nature of the 5-HT₄ receptors affecting the peristaltic reflex in the isolated rat distal colon. A single peristaltic reflex was evoked by infusing Tyrode solution into the lumen of the isolated segment using our modified Trendelenburg's method under an isovolumic condition. A 5-HT₄ receptor agonist, mosapride (10 nM), did not affect the threshold pressure and the propagation distance of the reflex contraction, but significantly increased the developed pressure (maximum pressure-threshold pressure) from 19.1±11.8 cm H₂O in the control to 26.8±13.0 cm H₂O (n=8, P<0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT₄ receptor enhances the propulsive power to move the luminal contents in the rat distal colon.

Original language	English
Pages (from-to)	62-65
Number of pages	4
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	99
Issue number	1
DOIs	https://doi.org/10.1016/S1566-0702(02)00063-2
State	Published - 2002/07/31

Keywords

5-HT receptor
Agonist
Distal colon
Mosapride
Peristaltic reflex
Rat

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1016/S1566-0702(02)00063-2

Cite this

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title = "5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon",

abstract = "The present study was designed to investigate the nature of the 5-HT4 receptors affecting the peristaltic reflex in the isolated rat distal colon. A single peristaltic reflex was evoked by infusing Tyrode solution into the lumen of the isolated segment using our modified Trendelenburg's method under an isovolumic condition. A 5-HT4 receptor agonist, mosapride (10 nM), did not affect the threshold pressure and the propagation distance of the reflex contraction, but significantly increased the developed pressure (maximum pressure-threshold pressure) from 19.1±11.8 cm H2O in the control to 26.8±13.0 cm H2O (n=8, P<0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT4 receptor enhances the propulsive power to move the luminal contents in the rat distal colon.",

keywords = "5-HT receptor, Agonist, Distal colon, Mosapride, Peristaltic reflex, Rat",

author = "Makoto Kadowaki and Wang, {Xia Obiao} and Hidehiko Shimatani and Satoshi Yoneda and Miyako Takaki",

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AU - Kadowaki, Makoto

AU - Wang, Xia Obiao

AU - Shimatani, Hidehiko

AU - Yoneda, Satoshi

AU - Takaki, Miyako

PY - 2002/7/31

Y1 - 2002/7/31

N2 - The present study was designed to investigate the nature of the 5-HT4 receptors affecting the peristaltic reflex in the isolated rat distal colon. A single peristaltic reflex was evoked by infusing Tyrode solution into the lumen of the isolated segment using our modified Trendelenburg's method under an isovolumic condition. A 5-HT4 receptor agonist, mosapride (10 nM), did not affect the threshold pressure and the propagation distance of the reflex contraction, but significantly increased the developed pressure (maximum pressure-threshold pressure) from 19.1±11.8 cm H2O in the control to 26.8±13.0 cm H2O (n=8, P<0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT4 receptor enhances the propulsive power to move the luminal contents in the rat distal colon.

AB - The present study was designed to investigate the nature of the 5-HT4 receptors affecting the peristaltic reflex in the isolated rat distal colon. A single peristaltic reflex was evoked by infusing Tyrode solution into the lumen of the isolated segment using our modified Trendelenburg's method under an isovolumic condition. A 5-HT4 receptor agonist, mosapride (10 nM), did not affect the threshold pressure and the propagation distance of the reflex contraction, but significantly increased the developed pressure (maximum pressure-threshold pressure) from 19.1±11.8 cm H2O in the control to 26.8±13.0 cm H2O (n=8, P<0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT4 receptor enhances the propulsive power to move the luminal contents in the rat distal colon.

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KW - Distal colon

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