ω-Conotoxin-MVIID blocks an ω-conotoxin-GVIA-sensitive, high-threshold Ca2+ current in fish retinal ganglion cells

Toshihide Tabata; Baldomero M. Olivera; Andrew T. Ishida

doi:10.1016/0028-3908(96)84634-X

ω-Conotoxin-MVIID blocks an ω-conotoxin-GVIA-sensitive, high-threshold Ca²⁺ current in fish retinal ganglion cells

Toshihide Tabata, Baldomero M. Olivera, Andrew T. Ishida^*

^*Corresponding author for this work

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Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Deduction of Ca²⁺ current amplitude by the Conus peptide ω-conotoxin-MVIID (ω-CTx-MVIID) was measured in voltage-clamped, goldfish retinal ganglion cells. Effects of depolarizing shifts in holding potential, and sequential applications of ω-CTx-MVIID, ω-CTx-GVIA, and BAY-K-8644, together with effects of Ni²⁺ and ω-Aga-IIIA, indicate that ω-CTx-MVIID may target Ca²⁺ channels differing from those termed T, L, N, P, Q and R.

Original language	English
Pages (from-to)	633-636
Number of pages	4
Journal	Neuropharmacology
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/0028-3908(96)84634-X
State	Published - 1996/05

Keywords

BAY-K-8644
Goldfish
Retinal ganglion cell
ω-conotoxin-GVIA
ω-conotoxin-MVIID

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0028-3908(96)84634-X

Cite this

@article{abc0d5937223450d8ac457438a00213c,

title = "ω-Conotoxin-MVIID blocks an ω-conotoxin-GVIA-sensitive, high-threshold Ca2+ current in fish retinal ganglion cells",

abstract = "Deduction of Ca2+ current amplitude by the Conus peptide ω-conotoxin-MVIID (ω-CTx-MVIID) was measured in voltage-clamped, goldfish retinal ganglion cells. Effects of depolarizing shifts in holding potential, and sequential applications of ω-CTx-MVIID, ω-CTx-GVIA, and BAY-K-8644, together with effects of Ni2+ and ω-Aga-IIIA, indicate that ω-CTx-MVIID may target Ca2+ channels differing from those termed T, L, N, P, Q and R.",

keywords = "BAY-K-8644, Goldfish, Retinal ganglion cell, ω-conotoxin-GVIA, ω-conotoxin-MVIID",

author = "Toshihide Tabata and Olivera, {Baldomero M.} and Ishida, {Andrew T.}",

note = "Funding Information: This work was supported by NIH grants EY 08120 to A.T. Ishida, and PO1 GM 28677 to B.M. Olivera. We thank Professor Y. Fukuda for the opportunity to pursue this study, A. Scriabine for a gift of BAY-K-8644, and G.J. Partida for preparing the primary cell cultures used in these experiments.",

year = "1996",

month = may,

doi = "10.1016/0028-3908(96)84634-X",

language = "英語",

volume = "35",

pages = "633--636",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Ltd.",

number = "5",

}

TY - JOUR

T1 - ω-Conotoxin-MVIID blocks an ω-conotoxin-GVIA-sensitive, high-threshold Ca2+ current in fish retinal ganglion cells

AU - Tabata, Toshihide

AU - Olivera, Baldomero M.

AU - Ishida, Andrew T.

N1 - Funding Information: This work was supported by NIH grants EY 08120 to A.T. Ishida, and PO1 GM 28677 to B.M. Olivera. We thank Professor Y. Fukuda for the opportunity to pursue this study, A. Scriabine for a gift of BAY-K-8644, and G.J. Partida for preparing the primary cell cultures used in these experiments.

PY - 1996/5

Y1 - 1996/5

N2 - Deduction of Ca2+ current amplitude by the Conus peptide ω-conotoxin-MVIID (ω-CTx-MVIID) was measured in voltage-clamped, goldfish retinal ganglion cells. Effects of depolarizing shifts in holding potential, and sequential applications of ω-CTx-MVIID, ω-CTx-GVIA, and BAY-K-8644, together with effects of Ni2+ and ω-Aga-IIIA, indicate that ω-CTx-MVIID may target Ca2+ channels differing from those termed T, L, N, P, Q and R.

AB - Deduction of Ca2+ current amplitude by the Conus peptide ω-conotoxin-MVIID (ω-CTx-MVIID) was measured in voltage-clamped, goldfish retinal ganglion cells. Effects of depolarizing shifts in holding potential, and sequential applications of ω-CTx-MVIID, ω-CTx-GVIA, and BAY-K-8644, together with effects of Ni2+ and ω-Aga-IIIA, indicate that ω-CTx-MVIID may target Ca2+ channels differing from those termed T, L, N, P, Q and R.

KW - BAY-K-8644

KW - Goldfish

KW - Retinal ganglion cell

KW - ω-conotoxin-GVIA

KW - ω-conotoxin-MVIID

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U2 - 10.1016/0028-3908(96)84634-X

DO - 10.1016/0028-3908(96)84634-X

M3 - 学術論文

C2 - 8887972

AN - SCOPUS:0030152018

SN - 0028-3908

VL - 35

SP - 633

EP - 636

JO - Neuropharmacology

JF - Neuropharmacology

IS - 5

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