α-klotho as a regulator of calcium homeostasis

Akihiro Imura; Yoshihito Tsuji; Miyahiko Murata; Ryota Maeda; Koji Kubota; Akiko Iwano; Chikashi Obuse; Kazuya Togashi; Makoto Tominaga; Naoko Kita; Ken Ichi Tomiyama; Junko Iijima; Yoko Nabeshima; Makio Fujioka; Ryo Asato; Shinzo Tanaka; Ken Kojima; Juichi Ito; Kazuhiko Nozaki; Nobuo Hashimoto; Tetsufumi Ito; Takeshi Nishio; Takashi Uchiyama; Toshihiko Fujimori; Yo Ichi Nabeshima

doi:10.1126/science.1135901

α-klotho as a regulator of calcium homeostasis

Akihiro Imura, Yoshihito Tsuji, Miyahiko Murata, Ryota Maeda, Koji Kubota, Akiko Iwano, Chikashi Obuse, Kazuya Togashi, Makoto Tominaga, Naoko Kita, Ken Ichi Tomiyama, Junko Iijima, Yoko Nabeshima, Makio Fujioka, Ryo Asato, Shinzo Tanaka, Ken Kojima, Juichi Ito, Kazuhiko Nozaki, Nobuo HashimotoTetsufumi Ito, Takeshi Nishio, Takashi Uchiyama, Toshihiko Fujimori, Yo Ichi Nabeshima^*

^*Corresponding author for this work

Systems Function & Morphology

Research output: Contribution to journal › Article › peer-review

374 Scopus citations

Abstract

α-klotho was identified as a gene associated with premature aging-like phenotypes characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and Na⁺,K ⁺-adenosine triphosphatase (Na⁺,K⁺-ATPase) and provide evidence for an increase of abundance of Na⁺,K ⁺-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca²⁺]_e) rapidly induce regulated parathyroid hormone (PTH) secretion in an α-Kl- and Na⁺,K ⁺-ATPase-dependent manner. The increased Na⁺ gradient created by Na⁺,K⁺-ATPase activity might drive the transepithelial transport of Ca²⁺ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of α-Kl in the regulation of calcium metabolism.

Original language	English
Pages (from-to)	1615-1618
Number of pages	4
Journal	Science
Volume	316
Issue number	5831
DOIs	https://doi.org/10.1126/science.1135901
State	Published - 2007/06/15

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Imura, A., Tsuji, Y., Murata, M., Maeda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N., Tomiyama, K. I., Iijima, J., Nabeshima, Y., Fujioka, M., Asato, R., Tanaka, S., Kojima, K., Ito, J., Nozaki, K., ... Nabeshima, Y. I. (2007). α-klotho as a regulator of calcium homeostasis. Science, 316(5831), 1615-1618. https://doi.org/10.1126/science.1135901

@article{554966c085204edfb204a49e0dc8f4cf,

title = "α-klotho as a regulator of calcium homeostasis",

abstract = "α-klotho was identified as a gene associated with premature aging-like phenotypes characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and Na+,K +-adenosine triphosphatase (Na+,K+-ATPase) and provide evidence for an increase of abundance of Na+,K +-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca2+]e) rapidly induce regulated parathyroid hormone (PTH) secretion in an α-Kl- and Na+,K +-ATPase-dependent manner. The increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of α-Kl in the regulation of calcium metabolism.",

author = "Akihiro Imura and Yoshihito Tsuji and Miyahiko Murata and Ryota Maeda and Koji Kubota and Akiko Iwano and Chikashi Obuse and Kazuya Togashi and Makoto Tominaga and Naoko Kita and Tomiyama, {Ken Ichi} and Junko Iijima and Yoko Nabeshima and Makio Fujioka and Ryo Asato and Shinzo Tanaka and Ken Kojima and Juichi Ito and Kazuhiko Nozaki and Nobuo Hashimoto and Tetsufumi Ito and Takeshi Nishio and Takashi Uchiyama and Toshihiko Fujimori and Nabeshima, {Yo Ichi}",

year = "2007",

month = jun,

day = "15",

doi = "10.1126/science.1135901",

language = "英語",

volume = "316",

pages = "1615--1618",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5831",

}

Imura, A, Tsuji, Y, Murata, M, Maeda, R, Kubota, K, Iwano, A, Obuse, C, Togashi, K, Tominaga, M, Kita, N, Tomiyama, KI, Iijima, J, Nabeshima, Y, Fujioka, M, Asato, R, Tanaka, S, Kojima, K, Ito, J, Nozaki, K, Hashimoto, N, Ito, T, Nishio, T, Uchiyama, T, Fujimori, T & Nabeshima, YI 2007, 'α-klotho as a regulator of calcium homeostasis', Science, vol. 316, no. 5831, pp. 1615-1618. https://doi.org/10.1126/science.1135901

TY - JOUR

T1 - α-klotho as a regulator of calcium homeostasis

AU - Imura, Akihiro

AU - Tsuji, Yoshihito

AU - Murata, Miyahiko

AU - Maeda, Ryota

AU - Kubota, Koji

AU - Iwano, Akiko

AU - Obuse, Chikashi

AU - Togashi, Kazuya

AU - Tominaga, Makoto

AU - Kita, Naoko

AU - Tomiyama, Ken Ichi

AU - Iijima, Junko

AU - Nabeshima, Yoko

AU - Fujioka, Makio

AU - Asato, Ryo

AU - Tanaka, Shinzo

AU - Kojima, Ken

AU - Ito, Juichi

AU - Nozaki, Kazuhiko

AU - Hashimoto, Nobuo

AU - Ito, Tetsufumi

AU - Nishio, Takeshi

AU - Uchiyama, Takashi

AU - Fujimori, Toshihiko

AU - Nabeshima, Yo Ichi

PY - 2007/6/15

Y1 - 2007/6/15

N2 - α-klotho was identified as a gene associated with premature aging-like phenotypes characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and Na+,K +-adenosine triphosphatase (Na+,K+-ATPase) and provide evidence for an increase of abundance of Na+,K +-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca2+]e) rapidly induce regulated parathyroid hormone (PTH) secretion in an α-Kl- and Na+,K +-ATPase-dependent manner. The increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of α-Kl in the regulation of calcium metabolism.

AB - α-klotho was identified as a gene associated with premature aging-like phenotypes characterized by short lifespan. In mice, we found the molecular association of α-Klotho (α-Kl) and Na+,K +-adenosine triphosphatase (Na+,K+-ATPase) and provide evidence for an increase of abundance of Na+,K +-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca2+]e) rapidly induce regulated parathyroid hormone (PTH) secretion in an α-Kl- and Na+,K +-ATPase-dependent manner. The increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of α-Kl in the regulation of calcium metabolism.

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U2 - 10.1126/science.1135901

DO - 10.1126/science.1135901

M3 - 学術論文

C2 - 17569864

AN - SCOPUS:34250803923

SN - 0036-8075

VL - 316

SP - 1615

EP - 1618

JO - Science

JF - Science

IS - 5831

ER -

α-klotho as a regulator of calcium homeostasis

Abstract

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