TY - JOUR
T1 - α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana
AU - Dang, Phu Hoang
AU - Nguyen, Hai Xuan
AU - Duong, Truc Thanh Thi
AU - Tran, Thao Kim Thi
AU - Nguyen, Phuc Thi
AU - Vu, Trang Kieu Thi
AU - Vuong, Hung Chi
AU - Phan, Nguyen Huu Trong
AU - Nguyen, Mai Thanh Thi
AU - Nguyen, Nhan Trung
AU - Awale, Suresh
N1 - Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.
PY - 2017/4/28
Y1 - 2017/4/28
N2 - From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A-F (1-6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical cancer cell line. In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-epi-10-deacetyltaxol (17) showed IC50 values of 0.05 and 0.085 nM, respectively, against HeLa cells.
AB - From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A-F (1-6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical cancer cell line. In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-epi-10-deacetyltaxol (17) showed IC50 values of 0.05 and 0.085 nM, respectively, against HeLa cells.
UR - http://www.scopus.com/inward/record.url?scp=85018414576&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.7b00006
DO - 10.1021/acs.jnatprod.7b00006
M3 - 学術論文
C2 - 28240909
AN - SCOPUS:85018414576
SN - 0163-3864
VL - 80
SP - 1087
EP - 1095
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 4
ER -