Involvement of SIRT1 activation in improving insulin sensitivity

SRT1720 treatment suppressed JNK signaling pathway, activated in white adipose tissue of high fat-fed mice. We constructed monocyte/macrophage specific SIRT1 knock out mice and fed high fat diet. In white adipose tissue of high fat-fed monocyte/macrophage specific SIRT1 knock out mice, inflammatory and hypoxia related genes were up-regulated compared with control mice. In conclusion, SIRT1 activation in macrophage was suggested to suppress inflammatory reaction in white adipose tissue of obese model.