Role of CD206 surface antigen on M2 macrophages in the development of insulin resistance in the diet-induced obese mice model

Project Details

Outline of Research at the Start

Furthermore, I will evaluate the underlying mechanism of how CD206 deficient macrophages are challenging to develop LAMs, how CD206+ M2-like macrophages uptake free fatty acids (FFA) to become LAMs, and how miRNAs derived from LAMs-exosome suppress metabolic favorable genes to develop insulin resistance.
StatusActive
Effective start/end date2024/04/01 → 2027/03/31

Funding

  • Japan Society for the Promotion of Science: ¥4,680,000.00

Keywords

  • Mrc1
  • M2 macrophage

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