Project Details
Outline of Research at the Start
Aging-related decline in NAD+ is reported to impair regenerative process. CD38 is an ectoenzyme to degrade NAD+ and is reportedly increased in inflammatory macrophages during aging. In this study, I will clarify the role of CD38 in the regulation of muscle stem cell functions in aged mice. Thus, my study may provide a clue that inhibition of CD38 restore functions of aged muscle stem cell functions. Reduction in CD38 boosts NAD+ and may rescue aging- and obesity-induced delay in muscle regeneration. Metabolic reprogramming in macrophages could open new field to boost the regenerative process.
| Status | Finished |
|---|---|
| Effective start/end date | 2022/04/01 → 2023/03/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,550,000.00
Keywords
- Muscle Regenration
- NAD metabolism
- Muscle Stem Cell
- Immune cells
- Aging