Molecular mechanism of apoptotic pathway through the tumor suppressor protein p53 approached from gene expression control

The general transcription factors TFIIE and TFIIH play essential roles in transcription initiation by RNA polymerase II. The possibility is shown that the phosphorylation modification of tumor suppressor protein p53 at serin 46 and threonine 55 influence the interaction of two factors. It is shown that p53 received DNA damage by ultraviolet and anti-cancer drug stabilized in the cell, the interaction with TFIIH is given to priority more than interactive with TFIIE by the post-translational modification of p53.