Design and Data Analysis for clinical pharmacokinetic trials to Evaluate Mechanisms for the Pharmacokinetic Variability

Hashimoto, Yukiya (Principal Investigator)
田口, 雅登 (Co-Investigator(Kenkyū-buntansha))
能澤, 孝 (Co-Investigator(Kenkyū-buntansha))
藤木, 明 (Co-Investigator(Kenkyū-buntansha))
Kayano, Yuichiro (Co-Investigator(Kenkyū-buntansha))

University of Toyama

16 Presentation
14 Article

14 results

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2008
Additional notes on clinical repeated-dose pharmacokinetic trials applying a peak-and-trough sampling design to estimate oral clearance
Takaai, M., Kayano, Y., Shimizu, T., Taguchi, M. & Hashimoto, Y., 2008, In: Drug Metabolism and Pharmacokinetics. 23, 2, p. 128-133 6 p.
Research output: Contribution to journal › Article › peer-review
4 Scopus citations
Contribution of Na⁺-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells
Takaai, M., Morishita, H., Ishida, K., Taguchi, M. & Hashimoto, Y., 2008/12/28, In: European Journal of Pharmacology. 601, 1-3, p. 61-65 5 p.
Research output: Contribution to journal › Article › peer-review
11 Scopus citations
Directional transcellular transport of bisoprolol in P-glycoprotein expressed LLC-GA5-COL150 cells, but not in renal epithelial LLC PK_1 Cells
K., T., Y, K., M, T., M., T. & Hashimoto Y., A., 2008, In: Drug Metab. Pharmacokinet 23. p. 340-346
Research output: Contribution to journal › Article › peer-review
Pharmacokinetics of R- and S-carvedilol in routinely treated Japanese patients with heart failure
Horiuchi, I., Nozawa, T., Fujii, N., Inoue, H., Honda, M., Shimizu, T., Taguchi, M. & Hashimoto, Y., 2008/05, In: Biological and Pharmaceutical Bulletin. 31, 5, p. 976-980 5 p.
Research output: Contribution to journal › Article › peer-review

Open Access
21 Scopus citations
Stereoselective oxidation and glucuronidation of carvedilol in human liver and intestinal microsomes
Ishida, K., Taira, S., Morishita, H., Kayano, Y., Taguchi, M. & Hashimoto, Y., 2008/06, In: Biological and Pharmaceutical Bulletin. 31, 6, p. 1297-1300 4 p.
Research output: Contribution to journal › Article › peer-review

Open Access
29 Scopus citations
The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells
Fukumori, S., Murata, T., Takaai, M., Tahara, K., Taguchi, M. & Hashimoto, Y., 2008, In: Drug Metabolism and Pharmacokinetics. 23, 5, p. 373-378 6 p.
Research output: Contribution to journal › Article › peer-review
7 Scopus citations
2007
Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males
Koue, T., Kubo, M., Funaki, T., Fukuda, T., Azuma, J., Takaai, M., Kayano, Y. & Hashimoto, Y., 2007/11, In: Biological and Pharmaceutical Bulletin. 30, 11, p. 2154-2158 5 p.
Research output: Contribution to journal › Article › peer-review

Open Access
15 Scopus citations
Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK₁ and Caco-2 cell monolayers
Takaai, M., Suzuki, H., Ishida, K., Tahara, K. & Hashimoto, Y., 2007/11, In: Biological and Pharmaceutical Bulletin. 30, 11, p. 2167-2172 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
18 Scopus citations
Population pharmacokinetics and proton pump inhibitory effects of intravenous lansoprazole in healthy Japanese males
Sakurai, Y., Hirayama, M., Hashimoto, M., Tanaka, T., Hasegawa, S., Irie, S., Ashida, K., Kayano, Y., Taguchi, M. & Hashimoto, Y., 2007/12, In: Biological and Pharmaceutical Bulletin. 30, 12, p. 2238-2243 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
15 Scopus citations
Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells.
Fukumori, S., Murata, T., Taguchi, M. & Hashimoto, Y., 2007/10, In: Drug Metabolism and Pharmacokinetics. 22, 5, p. 377-381 5 p.
Research output: Contribution to journal › Article › peer-review
26 Scopus citations
Simulation for clinical repeated-dose pharmacokinetic trials applying apeak-and-trough sampling design to estimate oral clearance
Ishida & Kazuya, 2007, In: Biol. Pharm. Bull 30. p. 2159-2162
Research output: Contribution to journal › Article › peer-review
Simulation for clinical repeated-dose pharmacokinetic trials applying a peak-and-trough sampling design to estimate oral clearance
Ishida, K., Kayano, Y., Taguchi, M. & Hashimoto, Y., 2007/11, In: Biological and Pharmaceutical Bulletin. 30, 11, p. 2159-2162 4 p.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations
Stereoselective metabolism of carvedilol by the beta naphthoflavone-inducible enzyme in human intestinal epithelial Caco-2 cells
K, I., M., H., T, S., M, T. & Hashimoto Y., A., 2007, In: Biol. Pharm. Bull 30. p. 1930-1933
Research output: Contribution to journal › Article › peer-review
UGT2B7*3 did not affect the pharmacokinetics of R- and S-carvedilol in healthy Japanese.
Honda, M., Toyoda, W., Shimizu, T., Horiuchi, I., Kayano, Y., Taguchi, M., Nozawa, T., Inoue, H. & Hashimoto, Y., 2007/10, In: Drug Metabolism and Pharmacokinetics. 22, 5, p. 382-386 5 p.
Research output: Contribution to journal › Article › peer-review
7 Scopus citations

Design and Data Analysis for clinical pharmacokinetic trials to Evaluate Mechanisms for the Pharmacokinetic Variability

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