Role of PDGF signal in normal and injured brain.

  • Sasahara, Masakiyo (PI)
  • Mori, Hisashi (CoI)
  • Ishii, Yoko (CoI)
  • Hamashima, Takeru (CoI)
  • Fukunaga, Kohji (CoI)

Project Details

Description

We analyzed the conditional knockout model of platelet-derived growth factor receptorβ(PDGFR-β). PDGFR-βpromoted the development of hippocampal pyramidal neurons and GABA neurons, and were involved in the development of cognitive ability and social behavior. PDGFR-βimproved the ischemic brain lesions, and was involved in neuroprotection, maturation of newly-formed blood vessels, the activation of neural stem cells and glial cell reaction. We established double knockout mouse model of PDGFR-αand-βgene for further PDGF research.
StatusFinished
Effective start/end date2008/04/012012/03/31

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