Project Details
Description
We analyzed the conditional knockout model of platelet-derived growth factor receptorβ(PDGFR-β). PDGFR-βpromoted the development of hippocampal pyramidal neurons and GABA neurons, and were involved in the development of cognitive ability and social behavior. PDGFR-βimproved the ischemic brain lesions, and was involved in neuroprotection, maturation of newly-formed blood vessels, the activation of neural stem cells and glial cell reaction. We established double knockout mouse model of PDGFR-αand-βgene for further PDGF research.
Status | Finished |
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Effective start/end date | 2008/04/01 → 2012/03/31 |
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