Interaction of anxiety with pain in the brain and new approach for improving the neuropathic pain-like state in mice

  • Yamazaki, Mitsuaki (Principal Investigator)
  • 佐々木, 利佳 (Co-Investigator(Kenkyū-buntansha))
  • Narita, Minoru (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

これらは、慢性疼痛(神経障害性疼痛)患者に対する治療戦略の手がかりとなりうる重要な所見であり、今後の臨床への応用が期待できる。
StatusFinished
Effective start/end date2007/01/012008/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,550,000.00

Keywords

  • neuropathic pain
  • anxiety
  • antidepressants
  • enriched environment
  • neurogenesis
  • hippocampus
  • nerve-ligated mice
  • doublecortin
  • NeuroD
  • dentate gyrus
  • light-dark test
  • elevated plus-maze test
  • amygdala
  • cingulated cortex
  • serotonin