Search for innate immune molecules and compounds that regulate adipose tissue inflammation

  • 長井良憲 (Principal Investigator)

Project Details

Outline of Final Research Achievements

We also demonstrated that isoliquiritigenin, a component of Glycyrrhiza uralensis, suppressed the expression of RP105/MD-1 and inflammatory cytokines. In vivo analyses revealed that supplementation of isoliquiritigenin inhibited HFD-induced inflammatory responses and IL-1β production in WAT, obesity, and insulin resistance.
StatusFinished
Effective start/end date2012/04/012015/03/31

Funding

  • Japan Society for the Promotion of Science: ¥5,460,000.00

Keywords

  • 免疫学
  • 自然免疫
  • 肥満
  • 天然薬物