Identification and functional analysis of genes for learning and memory dysfunction by using Senescence Accelerating Mouse

  • Masaharu, Isobe (Principal Investigator)
  • 黒澤, 信幸 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

4) The SAM strain specific polymorphism on chromosome 13 was found in a gene coding for an ion channel. When this gene was expressed in cultured cells, we found difference in ion permeability compared with normal control by patch clump methods. This difference suggests the involvement of the ion channel in learning and memory dysfunction although further characterizations are needed.
StatusFinished
Effective start/end date2004/01/012007/12/31

Funding

  • Japan Society for the Promotion of Science: ¥16,520,000.00

Keywords

  • SAM P8
  • JF1
  • 連鎖解析
  • 記憶学習障害
  • 老化
  • QTL analysis
  • Learning and Memory Dysfunction
  • Senescence