「痺れ」を伝達する末梢―脊髄ネットワーク機構の解明と治療薬の探索

歌大介 (Principal Investigator)
木口, 倫一 (Co-Investigator(Kenkyū-buntansha))

University of Toyama

Outline of Research at the Start

その為に①「痺れ」の脊髄情報伝達機構を可能にする新規in vivoパッチクランプ法の開発、②電気生理・行動薬理・生化学的解析法を駆使した治療薬の探索を行う。

Status	Active
Effective start/end date	2022/04/01 → 2026/03/31

Funding

Japan Society for the Promotion of Science: ¥4,160,000.00

Keywords

痺れ
痛み
シナプス伝達
電気生理学
in vivo記録
虚血再灌流
ニューロン
しびれ
異常感覚
In vivoパッチクランプ法
脊髄後角
末梢神経障害

Access Project

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K09020/

23 Presentation
8 Article

Combined experiments with in vivo fiber photometry and behavior tests can facilitate the measurement of neuronal activity in the primary somatosensory cortex and hyperalgesia in an inflammatory pain mice model.
Tatsuya, I., Daisuke, U., Hiroaki, O., Ilia, P., Kiyomi, H., Toshiaki, K. & Noriyuki, O., 2024, In: Biol. Pharm. Bull.. 47, 3, p. 591-599
Research output: Contribution to journal › Article › peer-review
Optogenetic gamma-band entrainment of parvalbumin-positive neurons in the primary sensory cortex facilitates the activity of spinal dorsal horn neurons and withdrawal response in mice.
T, O., D, U., K, Y., M, T., Y, K., J, M., T, S. & H., N., 2024.
Research output: Contribution to conference › Presentation
Study of Analgesic Effects of Laser Irradiation in Rats
Naoya, I. & Daisuke, U., 2024, In: The Journal of Japan Society for Laser Surgery and Medicine. 44, 4, p. 350-359
Research output: Contribution to journal › Article › peer-review