The role of cortico-hippocampal interaction for systems consolidation

We addressed the mechanism for systems consolidation and especially tested the hypothesis that “cortico-hippocampal co-activation following learning has an impact on systems consolidation”. To address this hypothesis, we developed the systems labeling and manipulating cell assembly activated during learning. Then, cortico-hippocampal neurons activated during learning were co-stimulated during sleep after learning. We observed mice tended to show that memory generalization was enhanced and hippocampal-dependency for memory retrieval was decreased. But to confirm these results, we have to improve methods for activating cell assembly.