Analysis of mechanism of latent infection and reactivation of varicella-zoster virus

  • Takemoto, Masaya (Principal Investigator)

Project Details

Abstract

Monoclonal antibody against glycoprotein H(gH) encoded by varicella-zoster virus(VZV) terminates lytic replication of VZV and induces the quiescently infected cells with dormant but recoverable VZV infectivity. It was demonstrated that autophagic clearance of intracellular gH and shedding microvesicle-mediated VZV virion outside the infected cells.
StatusFinished
Effective start/end date2010/01/01 → 2011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥3,900,000.00

Keywords

  • 抗原変調AV3(antigenic modulation)
  • shedding microvesicles
  • オートファジー
  • 水痘帯状疱疹ウイルス
  • glycoprotein H
  • glycoprotein H (gH)
  • 小胞体ストレス

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