Analysis of VZV latency induced by antigenic modulation

  • Shiraki, Kimiyasu (Principal Investigator)
  • Daikoku, Tohru (Co-Investigator(Renkei-kenkyūsha))
  • Takemoto, Masaya (Co-Investigator(Renkei-kenkyūsha))
  • Yajima, Misako (Co-Investigator(Renkei-kenkyūsha))
  • KUROSA, Yoshikazu (Research Collaborator)

Project Details

Outline of Final Research Achievements

Treatment with neutralizing antibody against varicella-zoster virus of infected cell induced antigenic modulation leading to latent state similar to the latency in neurons. Colocalization of the immediate early proteins and the transcription factor SP1 in untrated infected cells was altered by the antigenic modulation. Buthionine sulfoximine (BSO) treatment slowed the disappearance of their colocalization from the nucleus and prevented latent infection. Furthermore, Viral DNA become chromatin-associated status in latent infection, but BSO increased the amounts of chromainted free viral DNA.
StatusFinished
Effective start/end date2013/04/01 → 2018/03/31

Funding

  • Japan Society for the Promotion of Science: ¥17,160,000.00

Keywords

  • 水痘帯状疱疹ウイルス
  • 抗原変調
  • 潜伏感染
  • 中和抗体
  • ウイルス感染性
  • ウィルス
  • 転写因子
  • クロマチン
  • 抗原偏重作用
  • 帯状疱疹

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