Research output per year
Research output per year
Project Details
Abstract
In this study, I investigated the mechanism of mRNA expression of brain-derived neurotrophic factor （BDNF), which is involved in expressing a variety of neuronal functions. I found that RNA splicing of BDNF exon I-IX, which is one of alternative BDNF transcripts, was enhanced by Ca2+-CaMK signal evoked by neuronal activity. Moreover, a novel prepro-BDNF protein was generated from BDNF exon I-IX mRNA. These results provide a novel insight into BDNF expression in neurons
| Status | Finished |
|---|---|
| Effective start/end date | 2011/01/01 → 2012/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,290,000.00
Keywords
- BDNF
- スプライシング
- 神経活動
- BDNF前駆体
Research output
- 2 Article
-
Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter
Ihara, D., Fukuchi, M., Honma, D., Takasaki, I., Ishikawa, M., Tabuchi, A. & Tsuda, M., 2012/02, In: Neuropharmacology. 62, 2, p. 1091-1098 8 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons
Matsuya, Y., Ihara, D., Fukuchi, M., Honma, D., Itoh, K., Tabuchi, A., Nemoto, H. & Tsuda, M., 2012/04/15, In: Bioorganic and Medicinal Chemistry. 20, 8, p. 2564-2571 8 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations