Effects of septic condition on pacemaking cell.-Anti-arrhythmic strategy by gene-based treatments-

  • 畠山, 登 (Principal Investigator)
  • 青木優太 (Co-Investigator(Renkei-kenkyūsha))
  • 木下, 浩之 (Co-Investigator(Renkei-kenkyūsha))
  • 山本, 誠士 (Co-Investigator(Renkei-kenkyūsha))

Project Details

Abstract

In atrial myocytes from septic model of guinea pig, duration of action potential was significantly shortened. This may be the result of the nitration of the ion channels that would alter channel functions rather than the changes in atrial expression of the channels. The reduction of action potential duration could play a role for the development of atrial tachyarrhythmia in sepsis.
StatusFinished
Effective start/end date2009/01/012011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,420,000.00

Keywords

  • 敗血症
  • 不整脈
  • イオンチャネル
  • 全身性炎症反応症候群
  • 心筋
  • 活動電位
  • チャネル発現
  • カルシウムチャネル
  • カリウムチャネル
  • 全身性炎症症候群
  • 頻脈性不整脈
  • ショック
  • 心房筋