Clarification of properties of chloride channels, SLC26A7 and 26A9, involved in novel cytoprotective mechanism

  • 酒井, 秀紀 (Principal Investigator)
  • 森井, 孫俊 (Co-Investigator(Kenkyū-buntansha))
  • 清水, 貴浩 (Co-Investigator(Kenkyū-buntansha))
  • 藤井, 拓人 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

The gastric parietal cell secretes strong acid, but the cell is not digested by acid. Therefore, it is thought that the parietal cell possesses the sophisticated cytoprotective mechanism. So far, we found that function of a cytoprotective Cl^-channel is essential for the mechanism. In this study, we tried to clarify physiological function of two kinds of Cl^-channels, SLC26A7 and SLC26A9, in the parietal cell. We found that SLC26A7 is an essential molecule for maintaining the function of cytoprotective Cl^-channel, and that SLC26A9 is activated by acidic pH and inhibited by hyperosmolality
StatusFinished
Effective start/end date2009/01/01 → 2011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥11,830,000.00

Keywords

  • 胃酸分泌細胞
  • 細胞防御
  • ホメオスタシス
  • イオンチャネル
  • 塩化物イオン
  • トランスポーター
  • 塩素イオン
  • SLC26A7
  • SLC26A9
  • プロスタグランジン
  • ピロリ菌
  • インターロイキン

Access Project

View all 6 Research outputs